Role of IFN-lambda in host defense against respiratory virus infections

• Applicant: Professor Dr. Peter Stäheli
• Subject Area: Virology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317170439

• Final Report Year: 2019

Final Report Abstract

No abstract available

Publications

• Interferon-λ prevents influenza virus spread from the upper respiratory tract to the lungs and limits virus transmission. eLife 7: e33354 (2018)
  Klinkhammer, J., Schnepf, D., Ye, L., Schwaderlapp, M., Gad, H.H., Hartmann, H., Garcin, D., Mahlakõiv, T., & P. Staeheli
  (See online at https://doi.org/10.7554/eLife.33354)
• (2016). Role of Interferon-λ in the spread of influenza viruses from the upper respiratory tract to the lungs and in virus transmission among mice. Doktorarbeit, Medizinische Fakultät, Universität Freiburg
  Klinkhammer, J.
  
• (2019). Interferon-lambda: a cytokine controlling innate and adaptive antiviral mucosal immunity. Doktorarbeit, Fakultät für Biologie, Universität Freiburg
  Ye, L.
  
• (2019). Interferon-λ: a cytokine orchestrating innate and adaptive mucosal immune responses. Doktorarbeit, Fakultät für Biologie, Universität Freiburg
  Schnepf, D.
  
• Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin. Nature Immunology 20: 593-601 (2019)
  Ye, L., Schnepf, D., Becker, J., Ebert, K., Tanriver, Y., Bernasconi, V., Gad, H.H., Hartmann, R., Lycke, N., & P. Staeheli
  (See online at https://doi.org/10.1038/s41590-019-0345-x)
• Interferon-λ orchestrates innate and adaptive mucosal immune responses. Nature Reviews Immunology 19: 614-625 (2019)
  Ye, L., Schnepf, D, & P. Staeheli
  (See online at https://doi.org/10.1038/s41577-019-0182-z)
• Type I and type III interferons differ in their adjuvant activities for influenza vaccines. J. Virology 93: e01262 (2019)
  Ye, L., Ohnemus, A., Ong, L. C., Gad, H. H., Hartmann, R., Lycke, N. & P. Staeheli
  (See online at https://doi.org/10.1128/JVI.01262-19)