Role of mitofusin ubiquitylation in mitochondrial quality control (A03)

• Subject Area: Cell Biology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

Mitochondrial shape adapts to the cellular conditions, thanks to their capacity to undergo fusion and fission events. This dynamism is important to overcome stress, for example by assisting the elimination of the damaged organelles by mitophagy. Fusion components, called mitofusins, are hubs for stress signal integration and transformation into mitochondrial morphology and mitophagy regulation. The activity of mitofusins is regulated by ubiquitylation both in yeast and mammals. In this project, we want to unravel the molecular mechanisms governing mitofusins ubiquitylation and its implications in health and disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Dr. Mafalda Escobar-Henriques