Oxidative stress signalling and lipid metabolism in lifespan regulation (B01)

• Subject Area: Cell Biology
• Term: from 2016 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

Increasing body of evidence indicate that at moderate concentrations, ROS acts as a second messenger that regulates a number of signalling pathways. We identified a redox-regulated transcription factor KLF-1 as a mediator of a cytoprotective response that dictates longevity induced by reduced mitochondrial function. In particular we identified KLF-1 mediated regulation of peroxisomal lipid metabolism as essential for longevity assurance in mitochondrial that we intend to address in the second funding period.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Professorin Dr. Aleksandra Trifunovic