Ubiquitin-dependent coordination of mitochondrial-cytoplasmic quality control (B03)

• Subject Area: Cell Biology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

Mitochondrial functionality is supported by the ubiquitin/proteasome-system (UPS) either degrading damaged proteins or the entire organelle. Besides the role of branched-chain amino acid (BCAA) metabolism in mitochondrial-cytoplasmic quality control, we are interested in the Parkinson’s disease-related E3 ubiquitin ligases Parkin and CHIP, which team up in ubiquitylation of mitochondrial proteins. Mechanistic insights into the crosstalk between metabolic changes, stress signals, and ubiquitin-dependent regulation will help to develop new therapeutic strategies for metabolic and neurodegenerative diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Thorsten Hoppe