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Cell-type specific mitochondrial Ca2+ handling and selective vulnerability to mitochondrial dysfunction in different dopaminergic neuron populations (B07)

Subject Area Molecular Biology and Physiology of Neurons and Glial Cells
Term from 2016 to 2020
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409
 
We aim to understand if and how the different, neuron type specific dependence on mitochondrial Ca2+ handling might contribute to the selective vulnerability of certain neuron types to mitochondrial dysfunction. We will a) analyse how mitochondria contribute to controlling free cytosolic Ca2+ in dopaminergic midbrain neurons of the substantia nigra (SN) vs. the ventral tegmental area (VTA) and b) if cell-type specific differences in mitochondrial Ca2+ handling between these two neuron types might contribute to their differential susceptibility to neurodegeneration caused by mitochondrial dysfunction, as seen in ageing and Parkinson¿s disease.
DFG Programme Collaborative Research Centres
Applicant Institution Universität zu Köln
 
 

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