Fear network interactions underlying resilience to stress (B03)

• Subject Area: Biological Psychiatry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264810226

B03 investigates how interactions between the amygdala, hippocampus, prefrontal cortex and nucleus accumbens shape resilience to stress. To this end, we will record neural activity in all four structures simultaneously in mice before, during and after exposure to a chronic stressor. We will examine whether functional connectivity between these structures is associated with resilience to stress-induced impairments of social, cognitive and emotional functioning. Optogenetic manipulations will also be performed to test the causal contribution of these network interactions to resilient behavior.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1193: Neurobiology of Resilience to stress-related mental dysfunction: from understanding mechanisms to promoting prevention
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Co-Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Dr. Torfi Sigurdsson