Transportproteine der GI-Mucosa bei autoimmunen Darmkrankheiten

Applicant Professor Dr. Jörg-Dieter Schulzke

Subject Area Gastroenterology

Term from 2006 to 2014

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 31906442

Final Report Year 2009

Final Report Abstract

No abstract available

(2006) Stable transfection of the glucocorticoid receptor restores expression of the epithelial sodium channel in the intestinal monolayer HT-29/B6. Biochem. Biophys. Res. Comm. 344: 1065-1070
Zeissig S, Fromm A, Mankertz J, Zeitz M, Fromm M, Schulzke JD
(2007) Butyrate induces intestinal sodium absorption via Sp3-mediated transcriptional up-regulation of epithelial sodium channels. Gastroenterology 132: 236-248.
Zeissig S, Fromm A, Mankertz J, Weiske J, Zeitz M, Fromm M, Schulzke JD
(2007). Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56: 61-72
Zeissig S, Bürgel N, Günzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD
(2008) Altered ENaC Expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease. Gastroenterology 134: 1436-1447
Zeissig S, Bergann T, Fromm A, Bojarski C, Heller F, Guenther U, Zeitz M, Fromm M, Schulzke JD
(2009) A colonic mineralocorticoid receptor cell model expressing epithelial Na+ channels. Biochem. Biophys. Res. Commun. 382: 280-285
Bergann T, Plöger S, Fromm A, Zeissig S, Borden SA, Fromm M, Schulzke JD
(2009) Glucocorticoids and tumor necrosis factor-a synergize to induce absorption by the epithelial sodium channel in the colon. Gastroenterology 136: 933-942
Bergann T, Zeissig S, Fromm A, Richter JF, Fromm M, Schulzke JD