Project Details
Projekt
Phosphoinositide-based switches in endolysosomal membrane dynamics and signaling (A08)
Subject Area
Biochemistry
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 278001972
Phosphoinositides (PIPs) regulate membrane dynamics and cell signaling. In project A08 we aim to dissect the role of PI 3-phosphate as regulatory switches in the control of lysosome function. We capitalize on our finding that distinct PI 3-phosphates differentially regulate lysosome function and nutrient signaling to (i) identify novel lysosomal PI 3-phosphate-binding effector proteins and define their roles in controlling (ii) lysosomal nutrient signaling and protein turnover as well as (iii) lysosome position and dynamics. These studies will provide new insights into the mechanisms underlying PIP-based functional switches at lysosomes.
DFG Programme
CRC/Transregios
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Heads
Professor Volker Haucke, Ph.D.; Professor Dr. Carsten Schultz, until 9/2019
