Project Details
Molecular switches regulating stress granule oscillation (A14)
Subject Area
Cell Biology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 278001972
Stress granules (SGs) are cytosolic condensates that form under a variety of stress conditions such as virus infection and contain stalled mRNAs. The team of A. Ruggieri / G. Stoecklin (A14) discovered that chronic infection with hepatitis C virus leads to an oscillating SG response with ON and OFF phases of protein synthesis, regulated by the antagonistic action of two main switches, the double-stranded RNA-activated Protein Kinase R and GADD34, a regulatory subunit of Protein Phosphatase 1. The proposed work will establish molecular principles by which oscillating stress responses are achieved and serve as a cellular strategy to mount an effective anti-viral program while maintaining cellular homeostasis.
DFG Programme
CRC/Transregios
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Heads
Dr. Alessia Ruggieri, Ph.D.; Professor Dr. Georg Stoecklin