The sequential phases of apoptotic cell clearance by microglia and macrophages (A06)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: from 2017 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Microglia and CNS macrophages remove dead cell material in the developing, healthy and diseasedadult nervous system. While mostly viewed from the single cell angle, clearance of dead cell material(efferocytosis) in tissues is a population response of many phagocytes. To date, the criticalparameters defining the efferocytic capacity of macrophage and microglia populations are unknown.We will investigate (a) how single cell motility and cytoskeletal regulation influence this populationresponse, and (b) how metabolic pathways and organelle systems control the resolution of ingestedmaterial in phagocyte networks.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• International Connection: USA
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Tim Lämmermann, Ph.D.; Dr. Angelika Rambold, since 1/2021