Macrophage programming in cytomegalovirus encephalitis (B04)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Cytomegalovirus is intertwined with postnatal immune development. Mouse CMV (mCMV) transientlyreprograms differentiated macrophages (transcriptome, proteome) via Wnt-path-way engagement,inducing stem cell-like properties and altered migration. In encephalitis, mCMV spreads from CNSinterfaces, which are inhabited by distinct macrophage subsets. We will explore neonatal and adultmCMV encephalitis models to interlink reprogramming of CNS macrophage subsets with theirdevelopment, with long-term neurological damage, epigenetic modifications and the response tosubsequent infections.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Philipp Henneke