Function of C/EBPs in monocytes, macrophages and microglia (B11)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2017 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Pioneering transcription factors of the C/EBP family are key regulators of myelopoiesis and functional myelomonocytic diversification. Various C/EBP isoforms and dozens of post-translational C/EBP modifications downstream of signaling events may alter myeloid cell specification. We plan to elucidate the role of variegated C/EBP constituents on myeloid functions in microglia and monocytes using a two-tiered approach of targeted mouse genetics in combination with proteomics. These experiments are aimed to decipher C/EBP mediated immune and neuroimmune functions during healthy and inflammatory conditions.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Achim Leutz; Dr. Jörg Schönheit, until 7/2016