Rolle von Stress bei der Entwicklung des Syndroms des Polyzystischen Ovars (PCOS): Neuronale Mechanismen

• Antragsteller: Professor Dr. Artur Mayerhofer
• Fachliche Zuordnung: Gynäkologie und Geburtshilfe ; Nuklearmedizin, Strahlentherapie, Strahlenbiologie
• Förderung: Förderung von 2006 bis 2014
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 32481379

• Erstellungsjahr: 2013

Zusammenfassung der Projektergebnisse

Summary and conclusion: ARB-2 is expressed by multiple ovarian cells including GCs from primordial to antral follicular stages. Activation of ARB-2 in primary and small preantral follicles may depend on the supply of NE derived from innervating fibers. The positive correlation of ARB-2 expression with follicular size, indicates that it may be a marker of growing follicles. Furthermore, the presence of NE in monkey follicular fluid in higher levels as in serum is in line with data from the human ovary and indicates specific roles in this compartment. Limits of the study: Follicles with the strongest immunoreactive ARB-2 signals, i.e. primary follicles could not be tested in the culture system. Since the preantral follicles mentioned express FSHR and thus the culture conditions required FSH supplementation, it is possible that ARB-2 mediated effects may have been masked.

Projektbezogene Publikationen (Auswahl)

• Norepinephrine, active norepinephrine transporter, and norepinephrine-metabolism are involved in the generation of reactive oxygen species in human ovarian granulosa cells. Endocrinology. 2012 Mar;153(3):1472-83
  Saller S, Merz-Lange J, Raffael S, Hecht S, Pavlik R, Thaler C, Berg D, Berg U, Kunz L, Mayerhofer A
  
• Ovarian norepinephrine, beta-2 adrenergic receptors and follicular growth. DGG-Tagung, München, Oktober 2012 (Posterprize)
  Merz C, Saller S, Spinnler K, Merz-Lange J, Kunz L, Xu J, Yeoman RR, Ting AY, Lawson MS, Stouffer RL, Hennebold J, Pau F, Dissen GA, Ojeda SR, Zelinski MB, Mayerhofer A
  
• Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation of reactive oxygen species (ROS) in granulosa cells: implication for physiology and pathology. Human Reproduction 27. Nov 2013 published online
  Saller S, Kunz L, Berg D, Berg U, Lara H, Urra J, Hecht S, Pavlik R, Thaler CJ, Mayerhofer A