Physical principles of chromosome organization and segregation by ParABS and SMC (P06)

• Subject Area: Biophysics
• Term: from 2017 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269423233

Chromosomal organization and segregation are controlled in part by a variety of DNA binding proteins in many bacteria. In Bacillus subtilis, the 3D chromosome organization depends sensitively on the widely conserved SMC condensin complexes and the ParABS segregation machinery. Our goal is to theoretically investigate the physical principles of how SMC and the ParABS system act together to spatially organize the chromosome, resolve replicating origins, and contribute to DNA segregation. In addition, we will collaborate with several members in this Transregio-CRC to elucidate the role of active processes in chromosome dynamics.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 174: Spatiotemporal dynamics of bacterial cells
• Applicant Institution: Philipps-Universität Marburg
• Project Head: Professor Dr. Chase Broedersz