Homeostatic regulation of protein copy numbers and its impact on neural network activity (C03)

• Subject Area: Experimental and Theoretical Network Neuroscience ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 221828878

We study the computational rules underlying homeostatic plasticity. Using experimental data from collaborators within the CRC1080, we will focus during the third funding period on the regulation of protein copy number during homeostatic plasticity by local protein synthesis and degradation (B01) and of synaptic AMPA receptor by endo- and exocytosis (B04). We will also use these results to model the impact of protein copy number on heterosynaptic plasticity and to derive predictions for network dynamics.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1080: Molecular and Cellular Mechanisms of Neural Homeostasis
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Dr. Tatjana Tchumatchenko, since 10/2021