Homeostatic regulation of REM-non REM transition in sleep (C04)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 221828878

One of the hallmarks of sleep is its homeostatic regulation: a lack of sleep is usually followed by compensatory excess of sleep and vice versa. After building a gene expression atlas of the lizard, we used these transcriptomic and electrophysiological data to identify in lizards the homolog of the mammalian claustrum and showed that it generates sharp wave and ripples (SWRs) during sleep. We now aim to characterize the morphological and functional relationships between the claustrum, the neighboring pallium and the cortex regarding SWR generation and propagation, their influence on cortical dynamics, their homeostatic regulation and their role in memory formation and transfer.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1080: Molecular and Cellular Mechanisms of Neural Homeostasis
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Gilles Laurent