Identifizierung und funktionelle Charakterisierung einer Oxytocin-Neuronen Population, die Laktation koordiniert
Molekulare Biologie und Physiologie von Nerven- und Gliazellen
Zusammenfassung der Projektergebnisse
We are currently preparing the complete set of results for a publication addressing longstanding question, which is vital for survival and propagation of mammalian species: how does the OT system is synchronized during lactation to efficiently control lactation. Our results propose a novel mechanism that a small fraction of parvocellular OT neurons, at least partially, controls lactation via receiving indirect synaptic input from sensory neurons of the spinal cord innervating the mammary glands. In turn, the same population of parvocellular OT neurons elicits coherent activation of magnocellular OT neurons in the PVN as well as in the SON to elicit pulsatile OT release into the blood to subsequently evoke milk ejection. However, the precise modalities and ascending pathways, which activates parvocellular OT neurons by the sensory stimuli in socially interacting virgin female rats and/or in lactating rats, remain further dissection.
Projektbezogene Publikationen (Auswahl)
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(2019): Chemogenetic activation of oxytocin neurons: Temporal dynamics, hormonal release, and behavioral consequences. Psychoneuroendocrinology 106, 77-84
Grund, T., Tang, Y., Benusiglio, D., Althammer, F., Probst, S., Oppenlander, L., Neumann, I.D., and Grinevich, V.
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(2019): Oxytocin signaling in the central amygdala modulates emotion discrimination in mice. Cur. Biol., 29, 1938-1953
Ferretti, V., Maltese, F., Contarini, G., Nigro, M., Bonavia, A., Huiping, H., Gigliucci, V., Morelli, G., Scheggia, D., Managò, F., Castellani, G., Lefevre, A., Cancedda, L., Bice Chini, B., Grinevich, V., and Papaleo, F.
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(2020): Distinct dynamics of social motivation drive different patterns of social behavior in Sprague Dawley rats and C57BL/6J mice. Nature Commun.
Netser, S., Meyer, A., Magalnik, H., Zylbertal, A., de la Zerda, S.H., Briller, M., Bizer, A., Grinevich, V., Wagner, S.
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(2020): Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance. PNAS
Duque-Wilckens, N., Torres, L., Yokoyama, S., Minie, V.A, Tran, A., Stela P. Petkova, S.P., Hao, R., Ramos-Maciel, S., Jackson, K., Pesavento, P., Iñiguez, S., Grinevich, V., Trainor, B.C.
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(2021): Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. Nature Neurosci., 24: 529-541
Wahis, J., Kerspern, D., Althammer, F., Baudon, A., Goyon, S., Hagiwara, D., Lefèvre, A., Boury-Jamot, B., Bellanger, B., Abatis, M., Silva da Gouveia, M., Benusiglio, D., Marina Eliava, Rozov, A., Weinsanto, I., Knobloch-Bollmann, H.S., Wang, H., Pertin, M., Inquimbert, P., Pitzer, C., Siemens, J., Goumon, Y., Boutrel, B., Darbon, P., Lamy, C.M., Stern, J.E., Décosterd,I., Chatton, J-Y., Young, W.S., Stoop, R., Poisbeau, P., Grinevich, V., Charlet, A.
