Identifizierung und funktionelle Charakterisierung einer Oxytocin-Neuronen Population, die Laktation koordiniert

• Antragsteller: Professor Dr. Valery Grinevich
• Fachliche Zuordnung: Kognitive, systemische und Verhaltensneurobiologie ; Molekulare Biologie und Physiologie von Nerven- und Gliazellen
• Förderung: Förderung von 2017 bis 2020
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 341162785

• Erstellungsjahr: 2021

Zusammenfassung der Projektergebnisse

We are currently preparing the complete set of results for a publication addressing longstanding question, which is vital for survival and propagation of mammalian species: how does the OT system is synchronized during lactation to efficiently control lactation. Our results propose a novel mechanism that a small fraction of parvocellular OT neurons, at least partially, controls lactation via receiving indirect synaptic input from sensory neurons of the spinal cord innervating the mammary glands. In turn, the same population of parvocellular OT neurons elicits coherent activation of magnocellular OT neurons in the PVN as well as in the SON to elicit pulsatile OT release into the blood to subsequently evoke milk ejection. However, the precise modalities and ascending pathways, which activates parvocellular OT neurons by the sensory stimuli in socially interacting virgin female rats and/or in lactating rats, remain further dissection.

Projektbezogene Publikationen (Auswahl)

• (2019): Chemogenetic activation of oxytocin neurons: Temporal dynamics, hormonal release, and behavioral consequences. Psychoneuroendocrinology 106, 77-84
  Grund, T., Tang, Y., Benusiglio, D., Althammer, F., Probst, S., Oppenlander, L., Neumann, I.D., and Grinevich, V.
  (Siehe online unter https://doi.org/10.1016/j.psyneuen.2019.03.019)
• (2019): Oxytocin signaling in the central amygdala modulates emotion discrimination in mice. Cur. Biol., 29, 1938-1953
  Ferretti, V., Maltese, F., Contarini, G., Nigro, M., Bonavia, A., Huiping, H., Gigliucci, V., Morelli, G., Scheggia, D., Managò, F., Castellani, G., Lefevre, A., Cancedda, L., Bice Chini, B., Grinevich, V., and Papaleo, F.
  (Siehe online unter https://doi.org/10.1016/j.cub.2019.04.070)
• (2020): Distinct dynamics of social motivation drive different patterns of social behavior in Sprague Dawley rats and C57BL/6J mice. Nature Commun.
  Netser, S., Meyer, A., Magalnik, H., Zylbertal, A., de la Zerda, S.H., Briller, M., Bizer, A., Grinevich, V., Wagner, S.
  (Siehe online unter https://doi.org/10.1038/s41467-020-19569-0)
• (2020): Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance. PNAS
  Duque-Wilckens, N., Torres, L., Yokoyama, S., Minie, V.A, Tran, A., Stela P. Petkova, S.P., Hao, R., Ramos-Maciel, S., Jackson, K., Pesavento, P., Iñiguez, S., Grinevich, V., Trainor, B.C.
  (Siehe online unter https://doi.org/10.1073/pnas.2011890117)
• (2021): Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. Nature Neurosci., 24: 529-541
  Wahis, J., Kerspern, D., Althammer, F., Baudon, A., Goyon, S., Hagiwara, D., Lefèvre, A., Boury-Jamot, B., Bellanger, B., Abatis, M., Silva da Gouveia, M., Benusiglio, D., Marina Eliava, Rozov, A., Weinsanto, I., Knobloch-Bollmann, H.S., Wang, H., Pertin, M., Inquimbert, P., Pitzer, C., Siemens, J., Goumon, Y., Boutrel, B., Darbon, P., Lamy, C.M., Stern, J.E., Décosterd,I., Chatton, J-Y., Young, W.S., Stoop, R., Poisbeau, P., Grinevich, V., Charlet, A.
  (Siehe online unter https://doi.org/10.1038/s41593-021-00800-0)