Catalytic, Asymmetric Halogenations mediated by hypervalent Iodanes

• Applicant: Professorin Dr. Tanja Gulder
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2017 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 344007829

Carbon-halogen bonds constitute a privileged structural motif that often significantly influence the unique properties of organic molecules. Despite the tremendous utility of halogenated compounds, methods for the selective formation of such C,X bonds still constitute a major challenge. Hypervalent iodanes have lately proven to be valuable tools for the bromination and chlorination of alkenes. They are not only a metal-free, mild alternative to conventional halogenation reagents, but also offer the opportunity to explore novel and fascinating reactivities and thereby open new structural space within halogenation chemistry. Application of this promising hypervalent iodine chemistry in asymmetric chlorinations and brominations is thus a rewarding goal that will be addressed within the project by combining the advantages of hypervalent iodanes and chiral organocatalysts.

• DFG Programme: Research Grants