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Structural and functional characterization of complex protein modules involved in regulation of proteasomal activitiy (B04)

Fachliche Zuordnung Biophysik
Förderung Förderung von 2007 bis 2009
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 25065445
 
Understanding of modulation and regulation of proteasomal activity cannot be complete without structural information about proteins involved. So far structure, function and mechanism have been elucidated only for 20S proteasome and few regulatory components. Our aim is to determine the structure of the lid and the signalosome complex, playing major role in the first steps of recognition and degradation of folded proteins. We want to combine and expand structural methods for characterization of major compounds of the protein degradation machinery and to provide mechanistic and modular insights into its regulation.
DFG-Verfahren Sonderforschungsbereiche
Großgeräte pipetting robot
Gerätegruppe 1170 Kristallzüchtungsapparaturen, Kristallisationsanlagen
Antragstellende Institution Gemeinsam FU Berlin und HU Berlin durch:
Charité - Universitätsmedizin Berlin
Mitantragstellende Institution Humboldt-Universität zu Berlin
Teilprojektleiter Professor Dr. Michael Groll, bis 9/2007
 
 

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