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Transcriptional and translational mechanisms of starvation priming in Staphylococcus aureus increase tolerance to oxidative and electrophile stress (C08)

Subject Area Metabolism, Biochemistry and Genetics of Microorganisms
Term from 2017 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 190578797
 
Staphylococcus aureus acquires non-specific tolerance to redox-active compounds and antibiotics during entry into stationary phase (“starvation priming”). We will study the stressor-specific transcriptional mechanisms (AldA, MerA, MhqR) and the role of non-specific stationary phase factors, such as (p)ppGpp and σB, in starvation priming. The role of transcription regulation in starvation priming will be investigated via functional and structural studies of RNA polymerase with interacting factors (e.g. DNA helicase HelD/HelIV and regulators of ribosomal RNA synthesis). We will elucidate the mechanisms, which promote redox stress and antibiotics tolerance of starved S. aureus.
DFG Programme Collaborative Research Centres
Applicant Institution Freie Universität Berlin
 
 

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