The impact of chronic inflammation on fear extinction (A12)

• Subject Area: Personality Psychology, Clinical and Medical Psychology, Methodology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316803389

This translational project at the neuro-immune interface and the gut-brain axis aims to obtain deeper mechanistic insights into the behavioral and neural effects of chronic inflammation on fear learning and extinction. In a set of closely interlinked studies in patients and in a preclinical mouse model of inflammatory bowel disease, we will investigate the neurobiological underpinnings and clinically relevant factors driving inflammation-induced maladaptive learning and memory processes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1280: Extinction Learning
• Applicant Institution: Ruhr-Universität Bochum
• Project Heads: Professorin Dr. Sigrid Elsenbruch; Professor Dr. Harald Engler