The systemic influence of adrenal hypoxia pathway proteins: from physiological functions to pathological alterations (A02)

• Subject Area: Pharmacology ; Toxicology, Laboratory Medicine
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

Project A02 examines how pathways dependent on hypoxia-inducible factor (HIF) in the adrenal cortex affect systemic processes, such as immune regulation, vascular stability, and tissue integrity. Previous studies have identified HIF1α as a key regulator of steroidogenesis. Preliminary data indicate that chronically elevated endogenous glucocorticoids may impact hematopoiesis, skin healing, and intestinal vascular function. During the funding period, we plan to investigate these effects further and examine the role of the glucocorticoid–glucocorticoid receptor signaling axis in the hematopoietic, endothelial, and cardiovascular systems using established transgenic mouse models.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professor Dr. Triantafyllos Chavakis, until 7/2021; Professor Dr. Ali El-Armouche; Professor Ben Wielockx, Ph.D.