Adrenal stem cells under homeostatic and stress conditions (A06)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Cell Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

(I) Utilise in vitro differentiated murine ES cells to restore adrenal insufficiency.(II) Evaluate the behaviour of HPA axis progenitors following perturbation of the HPA axis in mice and humans. (III) Characterise the molecular dynamics involved in the pathogenesis of stress-associated disorders utilising omics approaches.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Cynthia L. Andoniadou, Ph.D., since 7/2021; Professor Stefan R. Bornstein, Ph.D., until 6/2021; Dr. Andreas Schedl, since 7/2021; Dr. Charlotte Steenblock, since 7/2021