Translating strategies for adrenal regeneration and healthy function (A06)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Cell Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

We will adapt our mouse differentiation protocol to human induced pluripotent stem cells (iPSCs) to generate steroid-producing adrenocortical cells for studying development and drug testing. Furthermore, this project investigates the complex interactions between the adrenal cortex and medulla, focusing on their hormonal regulation and developmental dynamics. Additionally, we will explore the effects of mutations linked to hereditary conditions and how stress impacts adrenocortical stem cells. Ultimately, this research aims to enhance treatments for adrenal diseases, including adrenal insufficiency.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• International Connection: France
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professorin Cynthia L. Andoniadou, Ph.D., since 7/2021; Professor Dr. Stefan R. Bornstein, until 6/2021; Dr. Andreas Schedl, since 7/2021; Dr. Charlotte Steenblock, since 7/2021