Metabolic regulation of adrenocortical function (A07)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

A07 studies the regulation of glucocorticoid production by adrenocortical lipid metabolism. Particularly, it examines the role of FADS2-dependent PUFA synthesis and regulation of cholesterol synthesis by polyamine metabolism in adrenocortical steroidogenesis and tumorigenesis. Human and mouse primary adrenocortical cells, adrenocortical carcinoma cell lines and mouse models will be employed. Moreover, they will examine the therapeutic potential of icosapent ethyl-mediated FADS2 downregulation in the reduction of chronically elevated cortisol in obese individuals.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Privatdozentin Dr. Vasileia Ismini Alexaki; Professorin Dr. Suzanne Eaton, until 6/2021 (†); Holger Henneicke, Ph.D., from 7/2021 until 12/2025