Pathophysiology and advanced approaches for subtyping and diagnostic stratification in primary aldosteronism (B15)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

B15 investigates the pathophysiology and diagnosis of aldosterone-producing adenomas (APAs). Single-nucleus transcriptome and epigenome APA data will be integrated with spatial transcriptomic and proteomic maps to identify genotype-linked mechanisms driving tumourigenesis. Plasma steroidome profiling from the 900-patient PROSALDO biobank, will couple molecular findings to clinical phenotypes. Newly discovered biomarkers will feed into a regulatory-compliant, machine-learning decision-support tool for streamlined stratification of patients with PA.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Heads: Professor Graeme Eisenhofer, Ph.D.; Professor Jacques W.M. Lenders, Ph.D., until 6/2021; Tracy Ann Williams, Ph.D.