Mechanisms of Wnt protein secretion (A01)

• Subject Area: Developmental Biology ; Cell Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

This project investigates Wnt secretion mechanisms from ligand producing cells. In the next funding period, we will assess context-dependent mechanisms of Wnt secretion in different tissues during development. A systematic investigation of secretion and dispersal of all Drosophila Wnts will be performed using endogenous tagging, high-resolution microscopy, and functional perturbations in different tissues. In addition, we will continue to dissect interactions of Evi/Wls with other proteins together with CRC collaborators. This will lead to a deeper understanding of how different Wnt ligands are secreted and distributed in various tissues in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1324: Mechanisms and functions of Wnt signaling
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Michael Boutros; Professorin Dr. Irmgard Sinning, from 7/2021 until 12/2025