SFB 1324:  Mechanisms and functions of Wnt signaling

• Subject Area: Biology
• Term: since 2017
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Mechanisms of Wnt protein secretion (Project Heads Boutros, Michael ;  Sinning, Irmgard )
• A02 - Mechanisms of vascular Wnt signaling during liver homeostasis and tumorigenesis (Project Head Augustin, Hellmut G. )
• A07 - Cell-specific activation of Wnt signaling in healing after myocardial infarction (Project Head Leuschner, Florian )
• A08 - Wnt pathway specificity in niche – stem cell control (Project Heads Bageritz, Josephine ;  Lohmann, Ingrid )
• B01 - Role of DDX56 in GSK3β regulation during Wnt signaling (Project Head Niehrs, Ph.D., Christof )
• B02 - Mechanism of oscillatory Wnt signaling dynamics and its role in vertebrate embryos (Project Heads Aulehla, Alexander ;  Simons, Matias )
• B03 - The roles of Wnt signaling in genome stability (Project Heads Acebrón, Sergio Pérez ;  Bastians, Holger )
• B05 - Mathematical modeling of spatio-temporal dynamics of Wnt signaling and its function in development and regeneration (Project Head Marciniak-Czochra, Anna )
• B06 - Orchestration of stem- and EMT-like phenotypes by Wnt signaling (Project Head Martin-Villalba, Ana )
• B07 - Uncovering novel molecular mechanisms within Wnt signaling (Project Heads Sinning, Irmgard ;  Özbek, Suat )
• B08 - Mechanism of AXIN1 degradation after MEK inhibition (Project Head Zhan, Tianzuo )
• B10 - Decoding the role and regulation of Wnt/STOP in drug-resistant cancer cells for personalized treatment strategies (Project Head Hinze, Laura )
• B11 - The role of Wnt signaling in controlling neuromesodermal progenitor cell plasticity in teleost species (Project Heads Aulehla, Alexander ;  Saunders, Lauren )
• Z01 - Central administration (Project Head Boutros, Michael )
• Z02 - Advanced fluorescence microscopy (Project Heads Davidson, Gary ;  Engel, Ulrike )
• Z03 - Advanced genetic screens and genome-engineering (Project Head Boutros, Michael )
• Z04 - Advanced proteomics (Project Head Krijgsveld, Jeroen )

Completed projects

• A03 - Ykt6-dependent trafficking of Wnts (Project Head Gross, Julia )
• A04 - Roles of lipids in Wnt secretion and signaling (Project Heads Boutros, Michael ;  Brügger, Britta )
• A05 - The Wnt code: Deciphering early Wnt interactions in Hydra (Project Heads Holstein, Thomas W. ;  Tanaka, Motomu )
• A06 - Quantitative fluorescence microscopy for the analysis of Wnt pathway interactions and dynamics (Project Heads Davidson, Gary ;  Nienhaus, Gerd Ulrich )
• B04 - Wnt signaling in fate determination of retinal precursors (Project Head Wittbrodt, Joachim )
• B09 - Wnt-cilia signaling in epithelial polarization and renal development (Project Heads Pereira, Gislene ;  Simons, Matias )

• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Participating University: Georg-August-Universität Göttingen; Heinrich-Heine-Universität Düsseldorf; Karlsruher Institut für Technologie
• Participating Institution: Deutsches Krebsforschungszentrum (DKFZ); European Molecular Biology Laboratory (EMBL)
• Spokespersons: Professor Dr. Michael Boutros, since 7/2021; Professor Dr. Thomas W. Holstein, until 6/2021