Mechanism of oscillatory Wnt signaling dynamics and its role in vertebrate embryos (B02)

• Subject Area: Developmental Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

A key objective of this funding period is to identify the mechanism that links the glycolytic metabolite FBP with the Wnt signaling pathway. For this, we will test the central hypothesis based on previous data that the FBP-Wnt signaling axis is mediated via Tcf7l2. We will conduct an in-depth investigation of how glycolysis regulates Wnt signaling during somite segmentation and kidney development. In addition, we will explore the role of the glycolysis-Wnt signaling axis in diabetes-associated embryopathy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1324: Mechanisms and functions of Wnt signaling
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Alexander Aulehla; Professor Dr. Matias Simons