Mathematical modeling of spatio-temporal dynamics of Wnt signaling and its function in development and regeneration (B05)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

This project develops mathematical models to study how Wnt signaling regulates pattern formation, stem cell dynamics, and tissue organization in development, regeneration, and cancer. We focus on three systems: pattern formation in Hydra, stem cell control in adult neurogenesis and glioblastoma, and stem cell identity in Drosophila niches. Our approach combines mathematical modeling with statistical inference and model-based data analysis. A key challenge is integrating mechanistic models with single-cell transcriptomics and spatial data. These models will enable rigorous hypothesis testing and uncover feedbacks and robustness principles in Wnt-mediated processes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1324: Mechanisms and functions of Wnt signaling
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Anna Marciniak-Czochra