Mathematical modeling of spatio-temporal dynamics of Wnt signaling and its function in development and regeneration (B05)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

The focus of this project is mathematical modeling of spatio-temporal dynamics of Wnt signaling leading to patterns of Wnt expression, and of their impact on symmetry breaking, tissue organization and maintenance. Mechanisms of pattern formation will be studied on the example of Hydra development and regeneration. The impact of Wnt signaling on stem cell activation and differentiation will be modelled in adult neurogenesis in mice. Mechanistic mathematical models will be built and validated iteratively, based on data provided by collaborating projects.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1324: Mechanisms and functions of Wnt signaling
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Anna Marciniak-Czochra