The ultrastructure of synapses in action (A01)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

The molecular and structural elements that are responsible for presynaptic plasticity are still little known. To understand them, we compared during the first funding period two different types of synapses, Schaffer collateral and mossy fiber synapses, in resting conditions. We will now analyse the short- and long-term activity processes in these synapses, using a combination of mouse genetics, organotypic hippocampal slice cultures, high-pressure freezing, freeze-substitution, and electron tomography.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Benjamin Cooper, Ph.D.