Structure of synaptic organelles by X-ray diffraction and imaging (A02)

• Subject Area: Biophysics
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

In this project we analysed the structure of synaptic vesicles by innovative X-ray methods, and found, among other findings, that synaptic vesicle structure changes strongly during neurotransmitter uptake. We also developed many technologies that will enable us, in the next funding period, to study whether proteins are organized in form of domains on the vesicles. If domains exist, we will also investigate how stereotypical these domains are, to understand the molecular organization of the vesicles.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Tim Salditt