Molecular-scale analysis of key points in synaptic activity (A03)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

During the second funding period we studied the molecular organization of several molecular assemblies in the synapse, including the extracellular matrix that stabilizes and connects the pre- and postsynaptic compartments. For the next funding period, we plan to employ ONE microscopy to analyse several key aspects of synaptic organization: the organization of major exo- and endocytosis proteins, the organization of protein scaffolds and receptors in the postsynaptic density, and the distribution of adhesion molecules.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professor Silvio-Olivier Rizzoli, Ph.D.; Professorin Dr. Nadja Anita Simeth-Crespi