Activity-dependent morphological changes at endbulb of Held synapses (A04)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

The endbulbs of Held are the first central synapses of the auditory pathway, and enable a thorough analysis of the link between synapse function and morphology. In the first funding period we investigated overall morphological changes, as well as the variability of the individual synapses, by employing several electron microscopy methods. We will now focus on the changes taking place in relation to chronic or acute changes in activity, focusing on synaptic vesicle pools.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professorin Dr. Carolin Wichmann