Surface mobility of glutamate receptors (A07)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Cell Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

PSD-95 provides slots for the anchoring of AMPA receptors (AMPAR), which mediate fast excitatory synaptic transmission. AMPARs show activity-dependent dynamics related to conformational changes upon binding to glutamate. We aim to provide a holistic view of synaptic dynamics by placing the movement of AMPARs in the context of pre- and postsynaptic protein diffusion. We will focus on surface AMPARs located at the PSD, therefore those directly involved in synaptic transmission.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Dr. Elisa D' Este; Professor Stefan W. Hell