SUMOylation and Neddylation at Synapses (A09)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

SUMOylation is a post-translational protein modification akin to ubiquitination, which involves the conjugation of the ubiquitin like proteins SUMO1, SUMO2, and SUMO3. It is a key protein modification required by every eukaryotic cell, is relevant to almost every cellular process, and can have very diverse consequences, e.g. on protein solubility, stability, and interactions. We propose to employ a set of novel genetically modified mouse models for a systematic, analysis of synaptic SUMO conjugation, and of altered synaptic SUMOylation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professor Dr. Nils Brose; Dr. Marilyn Tirard