In vitro reconstitution of inhibitory GABAergic postsynapses (B04)

• Subject Area: Biophysics
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

The assembly of the postsynaptic transmitter sensing machinery at inhibitory nerve cell synapses requires the intimate interplay between cell adhesion proteins, scaffold and adaptor proteins, and γ-aminobutyric acid (GABA) or glycine receptors. In the last funding period, we successfully developed an in vitro membrane system allowing us to analyze part of the protein machinery. We will continue this goal here, working mainly with the proteins neuroligin-2, CB2 and gephyrin.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professorin Dr. Claudia Steinem