Nanoscale geometric focusing of synaptic calcium domains (C02)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology ; Experimental and Theoretical Network Neuroscience
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

We propose to establish a comprehensive theory of nanoscale geometric focusing of synaptic calcium domains and to predict nanoscale patterns of preferred calcium sensor positioning, resulting in resources and a simulation toolbox to assess nanoscale geometric focusing effects from multimodal nanoscale assays of synapses and synaptic release sites. In particular, we propose to study how preferred sensor positioning depends on release face organization and buffer conditions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Fred Wolf