Modelling dendritic spine fluctuations (C03)

• Subject Area: Experimental and Theoretical Network Neuroscience ; Bioinformatics and Theoretical Biology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

In the first funding period, we have developed a mathematical model that describes the spatio-temporal processes of the dynamic pool of actin filaments from the postsynaptic spines in basal, resting conditions. In the second funding period, we will focus on synaptic plasticity and the role of actin-driven structural changes in this process. We will rely on the “tagging and capture hypothesis”, in which we see actin dynamics as a tag that in critical for synaptic plasticity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Dr. Michael Fauth; Professor Dr. Florentin Wörgötter, until 6/2021