Targetable nanoparticles for efficient translocation across gastrointestinal barriers (A05)

• Subject Area: Preparatory and Physical Chemistry of Polymers
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

We have discovered that worm-like polymer micelles are selectively taken up into the inflamed mucosa of patients with inflammatory bowel diseases. Selected modifications of the surface of these nanoparticles (e.g., by introduction of charges or targeting ligands) are expected to increase the uptake rate and enable an effective transport of anti-inflammatory drugs to local macrophages as main pro-inflammatory cells. This concept will be tested ex vivo on human macrobiopsies and in an advanced gut-on-a-chip model.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Johannes Brendel; Privatdozent Dr. Alexander Mosig, since 7/2021; Professor Dr. Andreas Stallmach