Multicomponent nanoparticles for efficient targeting of inflammatory signaling and memory in hematopoietic stem and myeloid cells (B01)

• Subject Area: Biological and Biomimetic Chemistry
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

We develop polymer-based nanoparticles with improved biocompatibility capable of gene delivery into cells in culture and in vivo into blood cells. The cohesin complex was identified as a new epigenetic mediator of inflammation signaling in hematopoietic stem cells. Now, we explore the role of cohesin in inflammation memory, and we develop polymer-based therapies for transient cohesion knockdown to ameliorate inflammation-induced tissue damage by inflammation signals and aging-related inflammation memory.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Karl Lenhard Rudolph; Dr.-Ing. Anja Träger