Nuclear Pore Complex (NPC) alterations and functional implications in hepatocarcinogenesis (B04)

• Subject Area: Pathology
• Term: from 2017 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314905040

Project B04 (Singer; Nuclear Pore Complex (NPC) alterations and functional implications in hepatocarcinogenesis) has previously shown that components of the nuclear pore complex are not simple gates for nucleo-cytoplasmic transport but specifically regulate key tumor-relevant factors, such as p53. The proposed project will provide a comprehensive description of liver cancer associated changes in nuclear pore composition and their mechanistic consequences for oncogenic and tumor-suppressive pathways.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 209: Liver Cancer - New mechanistic and therapeutic concepts in a solid tumor model
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Stephan Singer