Selective targeting of hepatocytes using multifunctional block copolymer micelles to restore critical cellular signaling functions (C03)

• Subject Area: Immunology
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

The aim of this project is to design multifunctional core-shell-corona micelles with controllable size, net charge, and charge density that allow for cell-type specific delivery of siRNA into hepatocytes while deliberately avoiding macrophages. Covalent placement of targeting dyes on the surface of the nanostructures (e.g., polymethine dyes) will be a strategy to achieve an efficient and cell-type specific delivery of phosphoinositid-3-kinase (PI3K)-γ attacking substances reflecting a promising strategy to prevent sepsis-associated hepatic dysfunction.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Michael Bauer; Professorin Dr. Britta Qualmann; Professor Dr. Felix H. Schacher