Die Rolle des Energiemangels in der Entstehung der neovaskulären altersabhängigen Makuladegeneration

• Antragsteller: Dr. Bertan Cakir
• Fachliche Zuordnung: Augenheilkunde
• Förderung: Förderung von 2017 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 390146606

• Erstellungsjahr: 2020

Zusammenfassung der Projektergebnisse

Overall, we found that high plasma glucose levels and signs of insulin insensitivity during early postnatal life were associated with lower postnatal IGF-1 levels and increased risk of ROP. These findings were replicated in a neonatal hyperglycemia OIR mouse model also demonstrating that decreased insulin signaling suppressed liver production of IGF-I resulting in lower serum IGF-I levels and increased neovascularization in mouse OIR. IGF-1 supplementation improved revascularization and decreased pathological angiogenesis. The data further supports the use of IGF-1 supplementation as a potential treatment in hyperglycemic preterm infants to prevent ROP.

Projektbezogene Publikationen (Auswahl)

• (2018). Thrombocytopenia is associated with severe retinopathy of prematurity. JCI Insight 3
  Cakir, B., Liegl, R., Hellgren, G., Lundgren, P., Sun, Y., Klevebro, S., Löfqvist, C., Mannheimer, C., Cho, S., Poblete, A., et al.
  (Siehe online unter https://doi.org/10.1172/jci.insight.99448)