Die Rolle des Energiemangels in der Entstehung der neovaskulären altersabhängigen Makuladegeneration

• Antragsteller: Dr. Bertan Cakir
• Fachliche Zuordnung: Augenheilkunde
• Förderung: Förderung von 2017 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 390146606

• Erstellungsjahr: 2020

Zusammenfassung der Projektergebnisse

Overall, we found that high plasma glucose levels and signs of insulin insensitivity during early postnatal life were associated with lower postnatal IGF-1 levels and increased risk of ROP. These findings were replicated in a neonatal hyperglycemia OIR mouse model also demonstrating that decreased insulin signaling suppressed liver production of IGF-I resulting in lower serum IGF-I levels and increased neovascularization in mouse OIR. IGF-1 supplementation improved revascularization and decreased pathological angiogenesis. The data further supports the use of IGF-1 supplementation as a potential treatment in hyperglycemic preterm infants to prevent ROP.

Projektbezogene Publikationen (Auswahl)

• (2018). Thrombocytopenia is associated with severe retinopathy of prematurity. JCI Insight 3
  Cakir, Bertan; Liegl, Raffael; Hellgren, Gunnel; Lundgren, Pia; Sun, Ye; Klevebro, Susanna; Löfqvist, Chatarina; Mannheimer, Clara; Cho, Steve; Poblete, Alexander; Duran, Rubi; Hallberg, Boubou; Canas, Jorge; Lorenz, Viola; Liu, Zhi-Jian; Sola-Visner, Martha C.; Smith, Lois E.H. & Hellström, Ann