GSC 203:  Berlin-Brandenburg School for Regenerative Therapies (BSRT)

• Subject Area: Medicine
• Term: from 2007 to 2019
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 39052126

• Final Report Year: 2019

Final Report Abstract

The Berlin-Brandenburg School for Regenerative Therapies (BSRT) is a joint initiative of clinical, biological, and engineering sciences in the field of regenerative medicine. Its central goal is to provide the scientific basis for promoting endogenous tissue regeneration to combat acute and chronic diseases. This challenges traditional educational concepts since it requires the integration of cells, drugs and technical products into successful therapeutic approaches. Engineers need to understand biological mechanisms, biologists need a technical background and clinicians need basic biological and biomaterial knowledge. The key research targets of the BSRT are (1) the analysis of genomes and their functional interpretation; (2) a profound understanding of cell biology, cell-cell and cell-matrix interactions; (3) the development of skills for the functional assessment and manipulation of both cells and their environment (extracellular matrix, biomaterial scaffolds, molecular and mechanical boundary conditions) to foster regenerative cascades and (4) to develop an understanding of the biological deficits in regeneration in clinically demanding situations. Advances in the fields of cell biology, biochemistry, biotechnology, biomaterials, bioengineering, mechano-biology, in vivo imaging and bio-informatics have helped to make significant progress in the realisation of advanced therapies that enable enhancement of the endogenous repair processes in patients suffering from injury and degenerative diseases and to avoid long-term pharmacological treatment. Enabling advanced therapies requires a multidisciplinary approach and competences in various disciplines. Hence, with the help of the DFG funding, the BSRT has been able to develop and continuously improve a structural concept that addresses the interdisciplinary challenges of regenerative therapy research and is characterized by four main measures: 1 The interdisciplinary doctoral programme, which was established in the first funding period of the BSRT and has now been running very successfully for twelve years. 2 The Clinician Scientist programme that has been expanded across the whole Charité and which has been quoted as role model by the DFG “Senatskommission für Klinische Forschung”. 3 A dedicated PostDoc programme with special educational features that prepares young scientists for a future career in academia. We implemented a career track for outstanding junior researchers to establish their own independent research path early on with the support of the existing expertise in regenerative medicine in the Berlin-Brandenburg region. 4 The BioThinking programme, a new way of scientific communication and team building that we developed jointly with the Hasso Plattner Institute (HPI). This BioThinking programme enables inter- and trans-disciplinary research in a more structured and effective way by using coaching tools that have been adapted for the life sciences

Link to the final report

https://doi.org/10.2314/KXP:1699084963

Publications

• Treatment of PTLD with Rituximab and CHOP Reduces the Risk of Renal Graft Impairment after Reduction of Immunosuppression. American Journal of Transplantation. 2009;9(10):2331-7
  Trappe R, Hinrichs C, Appel U, Babel N, Reinke P, Neumayer HH, Budde K, Dreyling M, Dührsen U, Kliem V, Schüttrumpf S, Hauser IA, Mergenthaler HG, Schlattmann P, Anagnostopoulos I, Doerken B, Riess H
  (See online at https://doi.org/10.1111/j.1600-6143.2009.02772.x)
• Matricellular Signaling Molecule CCN1 Attenuates Experimental Autoimmune Myocarditis by Acting as a Novel Immune Cell Migration Modulator. Circulation. 2010;122(25):2688-U188
  Rother M, Krohn S, Kania G, Vanhoutte D, Eisenreich A, Wang XM, Westermann D, Savvatis K, Dannemann N, Skurk C, Hilfiker-Kleiner D, Cathomen T, Fechner H, Rauch U, Schultheiss HP, Heymans S, Eriksson U, Scheibenbogen C, Poller W
  (See online at https://doi.org/10.1161/CIRCULATIONAHA.110.945261)
• The challenges of modern interdisciplinary medical research. Nature biotechnology. 2011;29(12):1145-8
  von Roth P, Canny BJ, Volk HD, Noble JA, Prober CG, Perka C, Duda GN
  (See online at https://doi.org/10.1038/nbt.2062)
• BMP2 and mechanical loading cooperativelyregulate immediate early signalling events in the BMP pathway. BMC biology. 2012;10:37
  Kopf J, Petersen A, Duda GN, Knaus P
  (See online at https://doi.org/10.1186/1741-7007-10-37)
• Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women. The Journal of clinical endocrinology and metabolism. 2012;97(11):4061-70
  Hoeg A, Gogakos A, Murphy E, Mueller S, Kohrle J, Reid DM, Gluer CC, Felsenberg D, Roux C, Eastell R, Schomburg L, Williams GR
  (See online at https://doi.org/10.1210/jc.2012-2121)
• CCN1: a novel inflammation-regulated biphasic immune cell migration modulator. Cellular and molecular life sciences : CMLS. 2012;69(18):3101-13
  Lobel M, Bauer S, Meisel C, Eisenreich A, Kudernatsch R, Tank J, Rauch U, Kuhl U, Schultheiss HP, Volk HD, Poller W, Scheibenbogen C
  (See online at https://doi.org/10.1007/s00018-012-0981-x)
• Functional neurological recovery after spinal cord injury is impaired in patients with infections. Brain. 2012;135(Pt 11):3238-50
  Failli V, Kopp MA, Gericke C, Martus P, Klingbeil S, Brommer B, Laginha I, Chen Y, DeVivo MJ, Dirnagl U, Schwab JM
  (See online at https://doi.org/10.1093/brain/aws267)
• Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus. American journal of human genetics. 2012;91(4):629-35
  Spielmann M, Brancati F, Krawitz PM, Robinson PN, Ibrahim DM, Franke M, Hecht J, Lohan S, Dathe K, Nardone AM, Ferrari P, Landi A, Wittler L, Timmermann B, Chan D, Mennen U, Klopocki E, Mundlos S
  (See online at https://doi.org/10.1016/j.ajhg.2012.08.014)
• Intra-operatively customized implant coating strategies for local and controlled drug delivery to bone. Advanced drug delivery reviews. 2012;64(12):1142-51
  Trajkovski B, Petersen A, Strube P, Mehta M, Duda GN
  (See online at https://doi.org/10.1016/j.addr.2012.05.016)
• Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature. 2012;484(7395):514-8
  Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
  (See online at https://doi.org/10.1038/nature10957)
• The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts. Biomaterials. 2012;33(16):4059-68
  Drews K, Tavernier G, Demeester J, Lehrach H, De Smedt SC, Rejman J, Adjaye J
  (See online at https://doi.org/10.1016/j.biomaterials.2012.02.025)
• A GDF5 Point Mutation Strikes Twice - Causing BDA1 and SYNS2. Plos Genet. 2013;9(10):e1003846
  Degenkolbe E, Konig J, Zimmer J, Walther M, Reissner C, Nickel J, Ploger F, Raspopovic J, Sharpe J, Dathe K, Hecht JT, Mundlos S, Doelken SC, Seemann P
  (See online at https://doi.org/10.1371/journal.pgen.1003846)
• A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. Plos Genet. 2013;9(10):e1003846
  Degenkolbe E, Konig J, Zimmer J, Walther M, Reissner C, Nickel J, Ploger F, Raspopovic J, Sharpe J, Dathe K, Hecht JT, Mundlos S, Doelken SC, Seemann P
  (See online at https://doi.org/10.1371/journal.pgen.1003846)
• Architecture of the osteocyte network correlates with bone material quality. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2013;28(8):1837-45
  Kerschnitzki M, Kollmannsberger P, Burghammer M, Duda GN, Weinkamer R, Wagermaier W, Fratzl P
  (See online at https://doi.org/10.1002/jbmr.1927)
• BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells. Biomaterials. 2013;34(38):9789-802
  Lichtner B, Knaus P, Lehrach H, Adjaye J
  (See online at https://doi.org/10.1016/j.biomaterials.2013.08.084)
• Distinct global shifts in genomic binding profiles of limb malformation-associated HOXD13 mutations. Genome research. 2013;23(12):2091-102
  Ibrahim DM, Hansen P, Rodelsperger C, Stiege AC, Doelken SC, Horn D, Jager M, Janetzki C, Krawitz P, Leschik G, Wagner F, Scheuer T, Schmidt-von Kegler M, Seemann P, Timmermann B, Robinson PN, Mundlos S, Hecht J
  (See online at https://doi.org/10.1101/gr.157610.113)
• Investigation of the three-dimensional orientation of mineralized collagen fibrils in human lamellar bone using synchrotron X-ray phase nano-tomography. Acta biomaterialia. 2013;9(9):8118-27
  Varga P, Pacureanu A, Langer M, Suhonen H, Hesse B, Grimal Q, Cloetens P, Raum K, Peyrin F
  (See online at https://doi.org/10.1016/j.actbio.2013.05.015)
• Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion. Lab on a chip. 2013;13(18):3555-61
  Atac B, Wagner I, Horland R, Lauster R, Marx U, Tonevitsky AG, Azar RP, Lindner G
  (See online at https://doi.org/10.1039/c3lc50227a)
• The genetic predisposition of natural killer cell to BK virus-associated nephropathy in renal transplant patients. Kidney international. 2013;84(2):359-65
  Trydzenskaya H, Juerchott K, Lachmann N, Kotsch K, Kunert K, Weist B, Schonemann C, Schindler R, Nickel P, Melzig MF, Hugo C, Thomusch O, Neumann AU, Reinke P, Babel N
  (See online at https://doi.org/10.1038/ki.2013.59)
• Amino-polyvinyl Alcohol Coated Superparamagnetic Iron Oxide Nanoparticles are Suitable for Monitoring of Human Mesenchymal Stromal Cells In Vivo. Small. 2014;10(21):4340-51
  Schulze F, Dienelt A, Geissler S, Zaslansky P, Schoon J, Henzler K, Guttmann P, Gramoun A, Crowe LA, Maurizi L, Vallee JP, Hofmann H, Duda GN, Ode A
  (See online at https://doi.org/10.1002/smll.201400707)
• BMP2- induced chemotaxis requires PI3K p55gamma/p110alpha-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5beta recruitment at the cytocortex. BMC biology. 2014;12(1):43
  Hiepen C, Benn A, Denkis A, Lukonin I, Weise C, Boergermann JH, Knaus P
  (See online at https://doi.org/10.1186/1741-7007-12-43)
• IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells. Science translational medicine. 2014;6(241):241ra80
  Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE
  (See online at https://doi.org/10.1126/scitranslmed.3008706)
• Improved exome prioritization of disease genes through cross-species phenotype comparison. Genome biology. 2014;24(2):340-8
  Robinson PN, Kohler S, Oellrich A, Sanger Mouse Genetics P, Wang K, Mungall CJ, Lewis SE, Washington N, Bauer S, Seelow D, Krawitz P, Gilissen C, Haendel M, Smedley D
  (See online at https://doi.org/10.1101/gr.160325.113)
• Interleukin-23 deficiency leads to impaired wound healing and adverse prognosis after myocardial infarction. Circulation Heart failure. 2014;7(1):161-71
  Savvatis K, Pappritz K, Becher PM, Lindner D, Zietsch C, Volk HD, Westermann D, Schultheiss HP, Tschope C
  (See online at https://doi.org/10.1161/CIRCHEARTFAILURE.113.000604)
• Interleukin-6 receptor inhibition modulates the immune reaction and restores titin phosphorylation in experimental myocarditis. Basic research in cardiology. 2014;109(6):449
  Savvatis K, Muller I, Frohlich M, Pappritz K, Zietsch C, Hamdani N, Grote K, Schieffer B, Klingel K, Van Linthout S, Linke WA, Schultheiss HP, Tschope C
  (See online at https://doi.org/10.1007/s00395-014-0449-2)
• Mechanical and structural properties of bone in non-critical and critical healing in rat. Acta biomaterialia. 2014;10(9):4009-19
  Hoerth RM, Seidt BM, Shah M, Schwarz C, Willie BM, Duda GN, Fratzl P, Wagermaier W
  (See online at https://doi.org/10.1016/j.actbio.2014.06.003)
• Microbe driven T helper cell differentiation: lessons from C. albicans and S. aureus. Experimental dermatology. 2014;23(11):795-8
  Zielinski CE
  (See online at https://doi.org/10.1111/exd.12493)
• Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation. American journal of human genetics. 2014;94(2):278-87
  Howard MF, Murakami Y, Pagnamenta AT, Daumer-Haas C, Fischer B, Hecht J, Keays DA, Knight SJ, Kolsch U, Kruger U, Leiz S, Maeda Y, Mitchell D, Mundlos S, Phillips JA, 3rd, Robinson PN, Kini U, Taylor JC, Horn D, Kinoshita T, Krawitz PM
  (See online at https://doi.org/10.1016/j.ajhg.2013.12.012)
• Novel GMP-compatible protocol employing an allogeneic B cell bank for clonal expansion of allospecific natural regulatory T cells. American journal of transplantation. 2014;14(3):594-606
  Landwehr-Kenzel S, Issa F, Luu SH, Schmuck M, Lei H, Zobel A, Thiel A, Babel N, Wood K, Volk HD, Reinke P
  (See online at https://doi.org/10.1111/ajt.12629)
• The influence of age on adaptive bone formation and bone resorption. Biomaterials. 2014;35(34):9290-301
  Birkhold AI, Razi H, Duda GN, Weinkamer R, Checa S, Willie BM
  (See online at https://doi.org/10.1016/j.biomaterials.2014.07.051)
• Aging Leads to a Dysregulation in Mechanically Driven Bone Formation and Resorption. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015;30(10):1864-73
  Razi H, Birkhold AI, Weinkamer R, Duda GN, Willie BM, Checa S
  (See online at https://doi.org/10.1002/jbmr.2528)
• Biomaterials based strategies for skeletal muscle tissue engineering: Existing technologies and future trends. Biomaterials. 2015;53:502-21
  Qazi TH, Mooney DJ, Pumberger M, Geissler S, Duda GN
  (See online at https://doi.org/10.1016/j.biomaterials.2015.02.110)
• Compressive Residual Strains in Mineral Nanoparticles as a Possible Origin of Enhanced Crack Resistance in Human Tooth Dentin. Nano letters. 2015;15(6):3729-34
  Forien JB, Fleck C, Cloetens P, Duda G, Fratzl P, Zolotoyabko E, Zaslansky P
  (See online at https://doi.org/10.1021/acs.nanolett.5b00143)
• Endomyocardial biopsy and ultrastructural changes in dilated cardiomyopathy: taking a 'deeper' look into patients' prognosis. Eur Heart J. 2015;36(12):708-10
  Savvatis K, Schultheiss HP, Tschope C
  (See online at https://doi.org/10.1093/eurheartj/ehu461)
• Human CD45RA FoxP3 Memory-Type Regulatory T Cells Show Distinct TCR Repertoires With Conventional T Cells and Play an Important Role in Controlling Early Immune Activation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2015;15(10):2625-35
  Lei H, Kuchenbecker L, Streitz M, Sawitzki B, Vogt K, Landwehr-Kenzel S, Millward J, Juelke K, Babel N, Neumann A, Reinke P, Volk HD
  (See online at https://doi.org/10.1111/ajt.13315)
• Long bone maturation is driven by pore closing: A quantitative tomography investigation of structural formation in young C57BL/6 mice. Acta biomaterialia. 2015;22:92-102
  Bortel EL, Duda GN, Mundlos S, Willie BM, Fratzl P, Zaslansky P
  (See online at https://doi.org/10.1016/j.actbio.2015.03.027)
• Mesenchymal stromal cells prevent allostimulation in vivo and control checkpoints of Th1 priming: Migration of human DC to lymph nodes and NK cell activation. Stem Cells. 2015;33(10):3097-99
  Consentius C, Akyuz L, Schmidt-Lucke JA, Tschope C, Pinzur L, Ofir R, Reinke P, Volk HD, Juelke K
  (See online at https://doi.org/10.1002/stem.2104)
• Microdeletions on 6p22.3 are associated with mesomelic dysplasia Savarirayan type. Journal of medical genetics. 2015;52(7):476-83
  Flottmann R, Wagner J, Kobus K, Curry CJ, Savarirayan R, Nishimura G, Yasui N, Spranger J, Van Esch H, Lyons MJ, DuPont BR, Dwivedi A, Klopocki E, Horn D, Mundlos S, Spielmann M
  (See online at https://doi.org/10.1136/jmedgenet-2015-103108)
• Selective cell targeting and lineage tracing of human induced pluripotent stem cells using recombinant avian retroviruses. Cellular and molecular life sciences : CMLS. 2015;72(23):4671- 807
  Hildebrand L, Seemann P, Kurtz A, Hecht J, Contzen J, Gossen M, Stachelscheid H
  (See online at https://doi.org/10.1007/s00018-015-1957-4)
• Skeletal maturity leads to a reduction in the strain magnitudes induced within the bone: A murine tibia study. Acta biomaterialia. 2015;13:301-10
  Razi H, Birkhold AI, Zaslansky P, Weinkamer R, Duda GN, Willie BM, Checa S
  (See online at https://doi.org/10.1016/j.actbio.2014.11.021)
• The Genomic Birthday Paradox: How Much Is Enough? Human mutation. 2015;36(10):989-97
  Krawitz P, Buske O, Zhu N, Brudno M, Robinson PN
  (See online at https://doi.org/10.1002/humu.22848)
• Actions from head to toe: An update on Bone/Body Morphogenetic Proteins in health and disease. Cytokine Growth Factor Rev. 2016;27:1-11
  Hiepen C, Yadin D, Rikeit P, Dorpholz G, Knaus P
  (See online at https://doi.org/10.1016/j.cytogfr.2015.12.006)
• Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice. Genome research. 2016;26(2):183-91
  Spielmann M, Kakar N, Tayebi N, Leettola C, Nurnberg G, Sowada N, Lupianez DG, Harabula I, Flottmann R, Horn D, Chan WL, Wittler L, Yilmaz R, Altmuller J, Thiele H, van Bokhoven H, Schwartz CE, Nurnberg P, Bowie JU, Ahmad J, Kubisch C, Mundlos S, Borck G
  (See online at https://doi.org/10.1101/gr.199430.115)
• Full-Field Calcium K-Edge X- ray Absorption Near-Edge Structure Spectroscopy on Cortical Bone at the Micron-Scale: Polarization Effects Reveal Mineral Orientation. Analytical chemistry. 2016;88(7):3826-35
  Hesse B, Salome M, Castillo-Michel H, Cotte M, Fayard B, Sahle CJ, De Nolf W, Hradilova J, Masic A, Kanngiesser B, Bohner M, Varga P, Raum K, Schrof S
  (See online at https://doi.org/10.1021/acs.analchem.5b04898)
• Looking beyond the genes: the role of non-coding variants in human disease. Hum Mol Genet. 2016;25(R2):R157-R65
  Spielmann M, Mundlos S
  (See online at https://doi.org/10.1093/hmg/ddw205)
• Multimodal correlative investigation of the interplaying micro-architecture, chemical composition and mechanical properties of human cortical bone tissue reveals predominant role of fibrillar organization in determining microelastic tissue properties. Acta biomaterialia. 2016;44:51-64
  Schrof S, Varga P, Hesse B, Schone M, Schutz R, Masic A, Raum K
  (See online at https://doi.org/10.1016/j.actbio.2016.08.001)
• Structural insights into BMP receptors: Specificity, activation and inhibition. Cytokine Growth Factor Rev. 2016;27:13-34
  Yadin D, Knaus P, Mueller TD
  (See online at https://doi.org/10.1016/j.cytogfr.2015.11.005)
• Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration. Biomaterials. 2016;99:95-108
  Pumberger M, Qazi TH, Ehrentraut MC, Textor M, Kueper J, Stoltenburg-Didinger G, Winkler T, von Roth P, Reinke S, Borselli C, Perka C, Mooney DJ, Duda GN, Geissler S
  (See online at https://doi.org/10.1016/j.biomaterials.2016.05.009)
• Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017;31(2):556-68
  Jarve A, Muhlstedt S, Qadri F, Nickl B, Schulz H, Hubner N, Ozcelik C, Bader M
  (See online at https://doi.org/10.1096/fj.201600613R)
• Biomaterials that promote cell-cell interactions enhance the paracrine function of MSCs. Biomaterials. 2017;140:103-14
  Qazi TH, Mooney DJ, Duda GN, Geissler S
  (See online at https://doi.org/10.1016/j.biomaterials.2017.06.019)
• Genome-Wide Binding of Posterior HOXA/D Transcription Factors Reveals Subgrouping and Association with CTCF. Plos Genet. 2017;13(1):e1006567
  Jerkovic I, Ibrahim DM, Andrey G, Haas S, Hansen P, Janetzki C, Gonzalez Navarrete I, Robinson PN, Hecht J, Mundlos S
  (See online at https://doi.org/10.1371/journal.pgen.1006567)
• Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature. Nature communications. 2017;8(1):2153
  Reismann D, Stefanowski J, Gunther R, Rakhymzhan A, Matthys R, Nutzi R, Zehentmeier S, Schmidt-Bleek K, Petkau G, Chang HD, Naundorf S, Winter Y, Melchers F, Duda G, Hauser AE, Niesner RA
  (See online at https://doi.org/10.1038/s41467-017-01538-9)
• Multi-elemental nanoparticle exposure after tantalum component failure in hip arthroplasty: In-depth analysis of a single case. Nanomedicine. 2017;13(8):2415-23
  Schoon J, Geissler S, Traeger J, Luch A, Tentschert J, Perino G, Schulze F, Duda GN, Perka C, Rakow A
  (See online at https://doi.org/10.1016/j.nano.2017.08.004)
• Mutations in MYO1H cause a recessive form of central hypoventilation with autonomic dysfunction. Journal of medical genetics. 2017;54(11):754-61
  Spielmann M, Hernandez-Miranda LR, Ceccherini I, Weese-Mayer DE, Kragesteen BK, Harabula I, Krawitz P, Birchmeier C, Leonard N, Mundlos S
  (See online at https://doi.org/10.1136/jmedgenet-2017-104765)
• Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017;31(11):4720-33
  Benn A, Hiepen C, Osterland M, Schutte C, Zwijsen A, Knaus P
  (See online at https://doi.org/10.1096/fj.201700193RR)
• Stromal Cells Act as Guardians for Endothelial Progenitors by Reducing Their Immunogenicity After Co- Transplantation. Stem Cells. 2017;35(5):1233-45
  Souidi N, Stolk M, Rudeck J, Strunk D, Schallmoser K, Volk HD, Seifert M
  (See online at https://doi.org/10.1002/stem.2573)
• Synergistic antibiotic activity against planktonic and biofilm-embedded Streptococcus agalactiae, Streptococcus pyogenes and Streptococcus oralis. J Antimicrob Chemother. 2017;72(11):3085-92
  Gonzalez Moreno M, Trampuz A, Di Luca M
  (See online at https://doi.org/10.1093/jac/dkx265)
• T Lymphocytes Influence the Mineralization Process of Bone. Frontiers in immunology. 2017;8:562
  El Khassawna T, Serra A, Bucher CH, Petersen A, Schlundt C, Konnecke I, Malhan D, Wendler S, Schell H, Volk HD, Schmidt-Bleek K, Duda GN
  (See online at https://doi.org/10.3389/fimmu.2017.00562)
• The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration. Advanced healthcare materials. 2017;6(15)
  Zhukova Y, Hiepen C, Knaus P, Osterland M, Prohaska S, Dunlop JWC, Fratzl P, Skorb EV
  (See online at https://doi.org/10.1002/adhm.201601244)
• Ultrasounddriven titanium modification with formation of titania based nanofoam surfaces. Ultrason Sonochem. 2017;36:146-54
  Zhukova Y, Ulasevich SA, Dunlop JWC, Fratzl P, Mohwald H, Skorb EV
  (See online at https://doi.org/10.1016/j.ultsonch.2016.11.014)
• Bio- Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections. ACS Cent Sci. 2018;4(12):1624-32
  Czuban M, Srinivasan S, Yee NA, Agustin E, Koliszak A, Miller E, Khan I, Quinones I, Noory H, Motola C, Volkmer R, Di Luca M, Trampuz A, Royzen M, Mejia Oneto JM
  (See online at https://doi.org/10.1021/acscentsci.8b00344)
• Characterization of glycosylphosphatidylinositol biosynthesis defects by clinical features, flow cytometry, and automated image analysis. Genome Med. 2018;10(1):3
  Knaus A, Pantel JT, Pendziwiat M, Hajjir N, Zhao M, Hsieh TC, Schubach M, Gurovich Y, Fleischer N, Jager M, Kohler S, Muhle H, Korff C, Moller RS, Bayat A, Calvas P, Chassaing N, Warren H, Skinner S, Louie R, Evers C, Bohn M, Christen HJ, van den Born M, Obersztyn E, Charzewska A, Endziniene M, Kortum F, Brown N, Robinson PN, Schelhaas HJ, Weber Y, Helbig I, Mundlos S, Horn D, Krawitz PM.
  (See online at https://doi.org/10.1186/s13073-017-0510-5)
• Design of a migration assay for human gingival fibroblasts on biodegradable magnesium surfaces. Acta biomaterialia. 2018;79:158-67
  Amberg R, Elad A, Rothamel D, Fienitz T, Szakacs G, Heilmann S, Witte F
  (See online at https://doi.org/10.1016/j.actbio.2018.08.034)
• Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis. Nat Genet. 2018;50(10):1463-73
  Kragesteen BK, Spielmann M, Paliou C, Heinrich V, Schopflin R, Esposito A, Annunziatella C, Bianco S, Chiariello AM, Jerkovic I, Harabula I, Guckelberger P, Pechstein M, Wittler L, Chan WL, Franke M, Lupianez DG, Kraft K, Timmermann B, Vingron M, Visel A, Nicodemi M, Mundlos S, Andrey G
  (See online at https://doi.org/10.1038/s41588-018-0221-x)
• Hydrolytically-degradable click-crosslinked alginate hydrogels. Biomaterials. 2018;181:189-98
  Lueckgen A, Garske DS, Ellinghaus A, Desai RM, Stafford AG, Mooney DJ, Duda GN, Cipitria A
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