GSC 218:  Konstanzer Graduiertenschule Chemische Biologie

• Fachliche Zuordnung: Grundlagen der Biologie und Medizin ; Biologische Chemie und Lebensmittelchemie ; Mikrobiologie, Virologie und Immunologie
• Förderung: Förderung von 2007 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 39072414

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

Die Aufklärung molekularer Mechanismen physiologischer und pathophysiologischer Prozesse steht im Fokus der Grundlagenforschung und der angewandten Forschung. Um diese faszinierende, aber auch herausfordernde Aufgabe zu meistern, müssen die Expertise unterschiedlicher Disziplinen gebündelt und neue innovative Ansätze entwickelt werden. Entsprechend besteht an akademischen und industriellen Forschungseinrichtungen ein zunehmend großer Bedarf an Wissenschaftlern, die an der Schnittstelle von Chemie und Biologie ausgebildet sind. Daher wurde die Konstanzer Graduiertenschule Chemische Biologie (KoRS-CB) gegründet, um ein optimales Umfeld zum Training zukünftiger Wissenschaftler/innen an der Schnittstelle zwischen Chemie und Biologie zu schaffen. Das Forschungsprogramm der KoRS-CB stützt sich auf enge Kooperationen zwischen den Konstanzer Fachbereichen Biologie, Chemie und Informatik & Informationswissenschaft. Dieses interdisziplinäre Konzept hat signifikant an Momentum gewonnen und sich gegenseitig befruchtende Ansätze, um zelluläre Prozesse auf molekularer Ebene verstehen zu können, entwickelt. Das Curriculum der KoRS-CB zielt darauf ab, ihre Promovierenden mit aktuellen Forschungsthemen in einem interdisziplinären Ansatz vertraut zu machen und ihnen die Kompetenz zu vermitteln, komplexe biologische Prozesse auf molekularer Ebene zu verstehen und experimentell anzugehen. Dies versetzt die Promovierenden in die Lage, eine erfolgreiche Laufbahn in akademischen oder industriellen Einrichtungen einzuschlagen. Das Trainingsprogramm der KoRS-CB, das auf dem 2002 geschaffenen und von den Fachbereichen Chemie und Biologie gemeinsam getragenen Studiengang Life Science (Bachelor/Master) beruht, wird laufend weiterentwickelt, um konzeptionellen und technologischen Neuerungen und den stetig steigenden Ansprüchen hinsichtlich wissenschaftlicher Fertigkeiten und sog. Schlüsselqualifikationen gerecht zu werden. Zusammengefasst haben das Forschungs- und Ausbildungsprogramm der KoRS-CB in Kombination mit einer zunehmenden Integration von international renommierten Forschungsstätten die Universität Konstanz als ein national und international ausgewiesenes Zentrum für Chemische Biologie platziert.

Link zum Abschlussbericht

https://dx.doi.org/10.2314/KXP:1698291612

Projektbezogene Publikationen (Auswahl)

• Enzymatic Synthesis of Multiple Spin-Labeled DNA. Angew. Chem. Int. Ed. 2008, 47, 6782-6785
  Obeid, Samra; Yulikov, Maxim; Jeschke, Gunnar & Marx, Andreas
  
• A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nature Medicine 2009, 15, 781-787
  Muchamuel, Tony; Basler, Michael; Aujay, Monette A; Suzuki, Erika; Kalim, Khalid W; Lauer, Christoph; Sylvain, Catherine; Ring, Eileen R; Shields, Jamie; Jiang, Jing; Shwonek, Peter; Parlati, Francesco; Demo, Susan D; Bennett, Mark K; Kirk, Christopher J & Groettrup, Marcus
  
• Artificial ribozyme switches containing natural riboswitch aptamer domains. Angew. Chem. Int. Ed. 2009, 48, 2715-2718
  Wieland, Markus; Benz, Armin; Klauser, Benedikt & Hartig, Jörg S.
  
• BTB-1: A small molecule inhibitor of the mitotic motor protein Kif18A. Angew. Chem. Int. Ed. 2009, 48, 9072-9076
  Catarinella, Mario; Grüner, Tamara; Strittmatter, Tobias; Marx, Andreas & Mayer, Thomas U.
  
• Human Telomeric Quadruplex Conformations Studied by Pulsed EPR. Angew. Chem. Int. Ed. 2009, 48, 9728-9730
  Singh, Vijay; Azarkh, Mykhailo; Exner, Thomas E.; Hartig, Jörg S. & Drescher, Malte
  
• Investigation of mRNA quadruplex formation in Escherichia coli. Nature Protocols 2009, 4, 1632-1640
  Wieland, Markus & Hartig, Jörg S.
  
• Small-Molecule-Dependent Regulation of Transfer RNA in Bacteria. Angew. Chem. Int. Ed. 2009, 48, 7564-7567
  Berschneider, Barbara; Wieland, Markus; Rubini, Marina & Hartig, Jörg S.
  
• Total Syntheses of Cytotoxic, Naturally Occurring Kalasinamide, Geovanine, and Marcanine A. Angew. Chem. Int. Ed. 2009, 48, 911-913
  Lang, Steffen & Groth, Ulrich
  
• A Highly Active DNA Polymerase with a Fluorous Core. Angew. Chem. Int. Ed. 2010, 49, 1324-1327
  Holzberger, Bastian; Rubini, Marina; Möller, Heiko M. & Marx, Andreas
  
• Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy. PNAS 2010, 107, 9111- 9116
  Eichmann, Cédric; Preissler, Steffen; Riek, Roland & Deuerling, Elke
  
• Replacing 32 Proline Residues by a Noncanonical Amino Acid Results in a Highly Active DNA Polymerase. J. Am. Chem. Soc. 2010, 132, 15708-15713
  Holzberger, Bastian & Marx, Andreas
  
• Replication through an abasic DNA lesion: structural basis for adenine selectivity. EMBO Journal 2010, 29, 1738-1747
  Obeid, Samra; Blatter, Nina; Kranaster, Ramon; Schnur, Andreas; Diederichs, Kay; Welte, Wolfram & Marx, Andreas
  
• Structural basis for the synthesis of nucleobase modified DNA polymerase. PNAS 2010, 107, 21327-21331
  Obeid, Samra; Baccaro, Anna; Welte, Wolfram; Diederichs, Kay & Marx, Andreas
  
• Structures of DNA polymerases caught processing sizeaugmented nucleotide probes. Angew. Chem. Int. Ed. 2010, 49, 5181-5184
  Betz, Karin; Streckenbach, Frank; Schnur, Andreas; Exner, Thomas; Welte, Wolfram; Diederichs, Kay & Marx, Andreas
  
• Synthesis of defined ubiquitin dimers. J. Am. Chem. Soc. 2010, 132, 16337-16339
  Eger, Silvia; Scheffner, Martin; Marx, Andreas & Rubini, Marina
  
• Barcode-modifizierte Nukleotide. Angew. Chem. Int. Ed. 2012, 51, 254-257
  Baccaro, Anna; Steck, Anna‐Lena & Marx, Andreas
  
• Emulsion Polymerization of Styrene and Methyl Methacrylate Using Cationic Switchable Surfactants. Macromolecules 2011, 44, 2501-2509
  Fowler, Candace I.; Muchemu, Christine M.; Miller, Ricarda E.; Phan, Lam; O’Neill, Catherine; Jessop, Philip G. & Cunningham, Michael F.
  
• Polymerization Catalyst Laser- Interference Patterning. Angew. Chem. Int. Ed. 2011, 50, 9665-9667
  Huber, Johannes; Scheinhardt, Benjamin; Geldhauser, Tobias; Boneberg, Johannes & Mecking, Stefan
  
• Small-Molecule-Triggered Manipulation of DNA Three-Way Junctions. J. Am. Chem. Soc. 2011, 133, 4706-4709
  Seemann, Isabelle T.; Singh, Vijay; Azarkh, Mykhailo; Drescher, Malte & Hartig, Jörg S.
  
• Combined Directed Metalation - Suzuki-Miyaura Cross Coupling Strategies. Synthesis of Isomeric Chromenopyridinones and Related Annulated Analogues. ChemInform 2013, 44, 18
  Snieckus, Victor; E. Miller, Ricarda; Sommer, Roman; Fan, Hope & Groth, Ulrich
  
• Immuno- and constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity. Cell 2012, 148, 727-738
  Huber, Eva M.; Basler, Michael; Schwab, Ricarda; Heinemeyer, Wolfgang; Kirk, Christopher J.; Groettrup, Marcus & Groll, Michael
  
• KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nature Chem. Biol. 2012, 8, 612-614
  Betz, Karin; Malyshev, Denis A; Lavergne, Thomas; Welte, Wolfram; Diederichs, Kay; Dwyer, Tammy J; Ordoukhanian, Phillip; Romesberg, Floyd E & Marx, Andreas
  
• Site-directed spin-labeling of nucleotides and the use of incell EPR to determine longrange distances in a biologically relevant environment. Nature Protocols 2013, 8, 131-147
  Azarkh, Mykhailo; Singh, Vijay; Okle, Oliver; Seemann, Isabelle T; Dietrich, Daniel R; Hartig, Jörg S & Drescher, Malte
  
• Structural insights into the potential of 4-fluoroproline to modulate biophysical properties of proteins. Chem. Sci. 2012, 3, 2924-2931
  Holzberger, Bastian; Obeid, Samra; Welte, Wolfram; Diederichs, Kay & Marx, Andreas
  
• Structures of KlenTaq DNA Polymerase Caught While Incorporating C5-Modified Pyrimidine and C7-Modified 7- Deazapurine Nucleoside Triphosphates. J. Am. Chem. Soc. 2012, 134, 11840-11843
  Bergen, Konrad; Steck, Anna-Lena; Strütt, Stefan; Baccaro, Anna; Welte, Wolfram; Diederichs, Kay & Marx, Andreas
  
• A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nature Chem. Biol. 2013, 9, 491-493
  Gisin, Jonathan; Schneider, Alexander; Nägele, Bettina; Borisova, Marina & Mayer, Christoph
  
• Fingerprinting Differential Active Site Constraints of ATPases. Chem. Sci. 2013, 4, 1588-1596
  Hacker, Stephan M.; Hardt, Norman; Buntru, Alexander; Pagliarini, Dana; Möckel, Martin; Mayer, Thomas U.; Scheffner, Martin; Hauck, Christof R. & Marx, Andreas
  
• Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption: Observing Ubiquitin Activation in Real Time. Angew. Chem. Int. Ed. 2013, 52, 11916-11919
  Hacker, Stephan M.; Pagliarini, Dana; Tischer, Thomas; Hardt, Norman; Schneider, Daniel; Mex, Martin; Mayer, Thomas U.; Scheffner, Martin & Marx, Andreas
  
• Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins. Cell 2013, 152, 5, 1184- 1194
  Nathan, James A.; Spinnenhirn, Valentina; Schmidtke, Gunter; Basler, Michael; Groettrup, Marcus & Goldberg, Alfred L.
  
• Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nature Commun. 2013, 4, 2993
  Min, WooKee; Bruhn, Christopher; Grigaravicius, Paulius; Zhou, Zhong-Wei; Li, Fu; Krüger, Anja; Siddeek, Bénazir; Greulich, Karl-Otto; Popp, Oliver; Meisezahl, Chris; Calkhoven, Cornelis F.; Bürkle, Alexander; Xu, Xingzhi & Wang, Zhao-Qi
  
• Red-Light-Controlled Protein- RNA Crosslinking with a Genetically Encoded Furan. Angew. Chem. Int. Ed. 2013, 52, 4690-4693
  Schmidt, Moritz J. & Summerer, Daniel
  
• Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides. J. Am. Chem. Soc. 2013, 135, 42, 15667-9
  Obeid, Samra; Bußkamp, Holger; Welte, Wolfram; Diederichs, Kay & Marx, Andreas
  
• Structural insights into DNA replication without hydrogen bonds. J. Am. Chem. Soc. 2013, 135, 49, 18637-43
  Betz, Karin; Malyshev, Denis A.; Lavergne, Thomas; Welte, Wolfram; Diederichs, Kay; Romesberg, Floyd E. & Marx, Andreas
  
• Structure and function of an RNA-reading thermostable DNA polymerase. Angew. Chem. Int. Ed. 2013, 52, 11935-11939
  Blatter, Nina; Bergen, Konrad; Nolte, Oliver; Welte, Wolfram; Diederichs, Kay; Mayer, Jutta; Wieland, Markus & Marx, Andreas
  
• The nascent polypeptideassociated complex is a key regulator of proteostasis. EMBO Journal 2013, 32, 10, 1451-1468
  Kirstein-Miles, Janine; Scior, Annika; Deuerling, Elke & Morimoto, Richard I.
  
• Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry. Angew. Chem. Int. Ed. 2013, 52, 4265-4268
  Niederwieser, Andrea; Späte, Anne‐Katrin; Nguyen, Long Duc; Jüngst, Christian; Reutter, Werner & Wittmann, Valentin
  
• A genetically encoded spin label for EPR distance measurements. J. Am. Chem. Soc. 2014, 136, 4, 1238-1241
  Schmidt, Moritz J.; Borbas, Julia; Drescher, Malte & Summerer, Daniel
  
• Chain terminating and clickable NAD+ analogues for labeling target proteins of ADP- ribosyltransferases. Angew. Chem. Int. Ed. 2014, 53, 8159-8162
  Wang, Yan; Rösner, Daniel; Grzywa, Magdalena & Marx, Andreas
  
• Direct Sensing of 5- Methylcytosine by Polymerase Chain Reaction. Angew. Chem. Int. Ed. 2014, 53, 31, 8154-8158,
  Aschenbrenner, Joos; Drum, Matthias; Topal, Hüsnü; Wieland, Markus & Marx, Andreas
  
• Dissecting ubiquitin signaling by linkage-defined and protease resistant ubiquitin chains. Angew. Chem. Int. Ed. 2014, 53, 47, 12925-12929
  Schneider, Tatjana; Schneider, Daniel; Rösner, Daniel; Malhotra, Saurav; Mortensen, Franziska; Mayer, Thomas U.; Scheffner, Martin & Marx, Andreas
  
• Gd(III)-PyMTA Label Is Suitable for In-Cell EPR. J. Am. Chem. Soc. 2014, 136, 43, 15366-15378
  Qi, Mian; Groß, Andreas; Jeschke, Gunnar; Godt, Adelheid & Drescher, Malte
  
• Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO Molecular Medicine 2014, 6, 5, 569-703
  Basler, Michael; Mundt, Sarah; Muchamuel, Tony; Moll, Carlo; Jiang, Jing; Groettrup, Marcus & Kirk, Christopher J.
  
• Modulating the pKa of a tyrosine in KlenTaq DNA polymerase that is crucial for abasic site bypass by in vivo incorporation of a noncanonical amino acid. ChemBioChem 2014, 15, 1735-1737
  Blatter, Nina; Prokup, Alexander; Deiters, Alexander & Marx, Andreas
  
• Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A. Nature Commun. 2014, 5, 4397
  Häfner, Julia; Mayr, Monika I.; Möckel, Martin M. & Mayer, Thomas U.
  
• Programmable and highly resolved in vitro detection of genomic 5-methylcytosine by TALEs Angew. Chem. Int. Ed. 2014, 53, 23, 6002-6006
  Kubik, Grzegorz; Schmidt, Moritz J.; Penner, Johanna E. & Summerer, Daniel
  
• Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit. Angew. Chem. Int. Ed. 2014, 53, 10247-10250
  Hacker, Stephan M.; Mortensen, Franziska; Scheffner, Martin & Marx, Andreas
  
• Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle. Nature 2014, 507, 114-117
  Denger, Karin; Weiss, Michael; Felux, Ann-Katrin; Schneider, Alexander; Mayer, Christoph; Spiteller, Dieter; Huhn, Thomas; Cook, Alasdair M. & Schleheck, David
  
• Synthetic Polyester from Algae Oil. Angew. Chem. Int. Ed. 2014 53, 26, 6800-6804
  Roesle, Philipp; Stempfle, Florian; Hess, Sandra K.; Zimmerer, Julia; Río Bártulos, Carolina; Lepetit, Bernard; Eckert, Angelika; Kroth, Peter G. & Mecking, Stefan
  
• An Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1. PNAS 2015, 112, 31, E4298-E4305
  Felux, Ann-Katrin; Spiteller, Dieter; Klebensberger, Janosch & Schleheck, David
  
• Chorismatase Mechanisms Reveal Fundamentally Different Types of Reaction in a Single Conserved Protein Fold. J. Am. Chem. Soc. 2015, 137, 34, 11032-11037
  Hubrich, Florian; Juneja, Puneet; Müller, Michael; Diederichs, Kay; Welte, Wolfram & Andexer, Jennifer N.
  
• Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation. Nature Protocols 2015, 10, 10, 1594-1611
  Rösner, Daniel; Schneider, Tatjana; Schneider, Daniel; Scheffner, Martin & Marx, Andreas
  
• DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplexderived DNAzyme. Chem. Commun. 2015, 51, 7379-7381
  Verga, D.; Welter, M.; Steck, A.-L. & Marx, A.
  
• Not4-dependent translational repression is important for cellular protein homeostasis in yeast. EMBO Journal 2015, 34, 12
  Preissler, Steffen; Reuther, Julia; Koch, Miriam; Scior, Annika; Bruderek, Michael; Frickey, Tancred & Deuerling, Elke
  
• Programmable Sensors of 5- Hydroxymethylcytosine. J. Am. Chem. Soc. 2015, 137, 1, 2-5
  Kubik, Grzegorz; Batke, Sabrina & Summerer, Daniel
  
• Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit. EMBO Reports 2015, 16, 11, 1501-1510
  Heim, Andreas; Konietzny, Anja & Mayer, Thomas U.
  
• Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination. PNAS 2015, 112, 32, 9872-9877
  Mortensen, Franziska; Schneider, Daniel; Barbic, Tanja; Sladewska-Marquardt, Anna; Kühnle, Simone; Marx, Andreas & Scheffner, Martin
  
• The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum. Science 2015, 348, 6231, 201-207
  Gamerdinger, Martin; Hanebuth, Marie Anne; Frickey, Tancred & Deuerling, Elke
  
• A cascading activity-based probe sequentially targets E1– E2–E3 ubiquitin enzymes. Nature Chem. Biol. 2016, 12, 7, 523-530
  Mulder, Monique P C; Witting, Katharina; Berlin, Ilana; Pruneda, Jonathan N; Wu, Kuen-Phon; Chang, Jer-Gung; Merkx, Remco; Bialas, Johanna; Groettrup, Marcus; Vertegaal, Alfred C O; Schulman, Brenda A; Komander, David; Neefjes, Jacques; El Oualid, Farid & Ovaa, Huib
  
• Bioorthogonally Functionalized NAD+ Analogues for In-Cell Visualization of Poly(ADP- Ribose) Formation. Angew. Chem. Int. Ed. 2016, 55, 27, 7660-7664
  Wallrodt, Sarah; Buntz, Annette; Wang, Yan; Zumbusch, Andreas & Marx, Andreas
  
• Designer Extracellular Matrix Based on DNA-Peptide Networks Generated by Polymerase Chain Reaction. Angew. Chem. Int. Ed. 2016, 55, 34, 10136-10140
  Finke, Alexander; Bußkamp, Holger; Manea, Marilena & Marx, Andreas
  
• Modified Nucleotides for Discrimination between Cytosine and the Epigenetic Marker 5-Methylcytosine. Angew. Chem. Int. Ed. 2016, 55, 9, 3229-3232
  von Watzdorf, Janina; Leitner, Kim & Marx, Andreas
  
• Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction. Nature Commun. 2016, 7, 13695
  Hanebuth, Marie A.; Kityk, Roman; Fries, Sandra J.; Jain, Alok; Kriel, Allison; Albanese, Veronique; Frickey, Tancred; Peter, Christine; Mayer, Matthias P.; Frydman, Judith & Deuerling, Elke
  
• Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation. Angew. Chem. Int. Ed. 2016, 55, 27, 11256-11260
  Buntz, Annette; Wallrodt, Sarah; Gwosch, Eva; Schmalz, Michael; Beneke, Sascha; Ferrando‐May, Elisa; Marx, Andreas & Zumbusch, Andreas
  
• Sequence-Specific Incorporation of Enzyme- Nucleotide Chimera by DNA Polymerases. Angew. Chem. Int. Ed. 2016, 55, 10131-10135
  Welter, Moritz; Verga, Daniela & Marx, Andreas
  
• Twister ribozymes as highly versatile expression platforms for artificial riboswitches. Nature Commun. 2016, 7, 12834
  Felletti, Michele; Stifel, Julia; Wurmthaler, Lena A.; Geiger, Sophie & Hartig, Jörg S.
  
• Visualization of Protein-Specific Glycosylation inside Living Cells. Angew. Chem. Int. Ed. 2016, 55, 6, 2262-2266
  Doll, Franziska; Buntz, Annette; Späte, Anne‐Katrin; Schart, Verena F.; Timper, Alexander; Schrimpf, Waldemar; Hauck, Christof R.; Zumbusch, Andreas & Wittmann, Valentin
  
• Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding. J. Am. Chem. Soc. 2017, 139, 12, 4254-4257
  Robotta, Marta; Cattani, Julia; Martins, Juliana Cristina; Subramaniam, Vinod & Drescher, Malte
  
• Engineering of a DNA Polymerase for Direct m(6) A Sequencing. Angew. Chem. Int. Ed. 2018, 57, 2, 417-421
  Aschenbrenner, Joos; Werner, Stephan; Marchand, Virginie; Adam, Martina; Motorin, Yuri; Helm, Mark & Marx, Andreas
  
• Identification of Proteins Interacting with Ubiquitin Chains. Angew. Chem. Int. Ed. 2017, 56, 15764-15768
  Zhao, Xiaohui; Lutz, Joachim; Höllmüller, Eva; Scheffner, Martin; Marx, Andreas & Stengel, Florian
  
• Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues. Beilstein J. Org. Chem. 2017, 13, 495-501
  Wallrodt, Sarah; Simpson, Edward L & Marx, Andreas
  
• Plastid thylakoid architecture optimizes photosynthesis in diatoms. Nature Commun. 2017, 8, 15885
  Flori, Serena; Jouneau, Pierre-Henri; Bailleul, Benjamin; Gallet, Benoit; Estrozi, Leandro F; Moriscot, Christine; Bastien, Olivier; Eicke, Simona; Schober, Alexander; Bártulos, Carolina Río; Maréchal, Eric; Kroth, Peter G; Petroutsos, Dimitris; Zeeman, Samuel; Breyton, Cécile; Schoehn, Guy; Falconet, Denis & Finazzi, Giovanni
  
• Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of a complexes for apoptosis regulation Nature Commun. 2017, 8, 1, 73
  Bleicken, Stephanie; Hantusch, Annika; Das, Kushal Kumar; Frickey, Tancred & Garcia-Saez, Ana J.
  
• Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair. Angew. Chem. Int. Ed. 2017, 56, 39, 12000-12003
  Betz, Karin; Kimoto, Michiko; Diederichs, Kay; Hirao, Ichiro & Marx, Andreas
  
• Valorization of Unconventional Lipids from Microalgae or Tall Oil via a Selective Dual Catalysis One-Pot Approach. J. Am. Chem. Soc. 2017, 139, 38, 13487-13491
  Hess, Sandra K.; Schunck, Natalie S.; Goldbach, Verena; Ewe, Daniela; Kroth, Peter G. & Mecking, Stefan
  
• Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20. EMBO Reports 2018, 19, 12
  Heim, Andreas; Tischer, Thomas & Mayer, Thomas U.
  
• Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Reports 2018, 19, 12, pii: e46512
  Basler, Michael; Lindstrom, Michelle M; LaStant, Jacob J; Bradshaw, J Michael; Owens, Timothy D; Schmidt, Christian; Maurits, Elmer; Tsu, Christopher; Overkleeft, Herman S; Kirk, Christopher J; Langrish, Claire L & Groettrup, Marcus
  
• Snapshots of a modified nucleotide moving through the confines of a DNA polymerase. PNAS 2018, 115, 40, 9992- 9997
  Kropp, Heike Maria; Dürr, Simon Leonard; Peter, Christine; Diederichs, Kay & Marx, Andreas
  
• Structural dynamics of the E6AP/UBE3A-E6-p53 enzymesubstrate complex. Nature Commun. 2018, 9, 4441
  Sailer, Carolin; Offensperger, Fabian; Julier, Alexandra; Kammer, Kai-Michael; Walker-Gray, Ryan; Gold, Matthew G.; Scheffner, Martin & Stengel, Florian
  
• The structure of the ubiquitinlike modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nature Commun. 2018, 9, 1, 3321
  Aichem, Annette; Anders, Samira; Catone, Nicola; Rößler, Philip; Stotz, Sophie; Berg, Andrej; Schwab, Ricarda; Scheuermann, Sophia; Bialas, Johanna; Schütz-Stoffregen, Mira C.; Schmidtke, Gunter; Peter, Christine; Groettrup, Marcus & Wiesner, Silke
  
• Widespread bacterial lysine degradation proceeding via glutarate and L-2- hydroxyglutarate. Nature Commun. 2018, 9, 1, 5071
  Knorr, Sebastian; Sinn, Malte; Galetskiy, Dmitry; Williams, Rhys M.; Wang, Changhao; Müller, Nicolai; Mayans, Olga; Schleheck, David & Hartig, Jörg S.
  
• A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia. PNAS 2019, 116, 8, 3171-3176
  Peck, Spencer C.; Denger, Karin; Burrichter, Anna; Irwin, Stephania M.; Balskus, Emily P. & Schleheck, David
  
• A tetracycline-dependent ribozyme switch allows conditional induction of gene expression in Caenorhabditis elegans. Nature Commun. 2019, 10, 1, 491
  Wurmthaler, Lena A.; Sack, Monika; Gense, Karina; Hartig, Jörg S. & Gamerdinger, Martin
  
• Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies. Mol. Cell 2019, 74, 4, 729- 741.e7
  Shen, Koning; Gamerdinger, Martin; Chan, Rebecca; Gense, Karina; Martin, Esther M.; Sachs, Nadine; Knight, Patrick D.; Schlömer, Renate; Calabrese, Antonio N.; Stewart, Katie L.; Leiendecker, Lukas; Baghel, Ankit; Radford, Sheena E.; Frydman, Judith & Deuerling, Elke
  
• Pyrite formation from FeS and H2S is mediated through microbial redox activity. PNAS 2019, 116, 14, 6897- 6902
  Thiel, Joana; Byrne, James M.; Kappler, Andreas; Schink, Bernhard & Pester, Michael
  
• The Structure of an Archaeal B- Family DNA Polymerase in Complex with a Chemically Modified Nucleotide. Angew. Chem. Int. Ed. 2019, 58, 16, 5457-5461
  Kropp, Heike M.; Diederichs, Kay & Marx, Andreas