GSC 218:  Konstanzer Graduiertenschule Chemische Biologie

• Fachliche Zuordnung: Grundlagen der Biologie und Medizin ; Biologische Chemie und Lebensmittelchemie ; Mikrobiologie, Virologie und Immunologie
• Förderung: Förderung von 2007 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 39072414

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

Die Aufklärung molekularer Mechanismen physiologischer und pathophysiologischer Prozesse steht im Fokus der Grundlagenforschung und der angewandten Forschung. Um diese faszinierende, aber auch herausfordernde Aufgabe zu meistern, müssen die Expertise unterschiedlicher Disziplinen gebündelt und neue innovative Ansätze entwickelt werden. Entsprechend besteht an akademischen und industriellen Forschungseinrichtungen ein zunehmend großer Bedarf an Wissenschaftlern, die an der Schnittstelle von Chemie und Biologie ausgebildet sind. Daher wurde die Konstanzer Graduiertenschule Chemische Biologie (KoRS-CB) gegründet, um ein optimales Umfeld zum Training zukünftiger Wissenschaftler/innen an der Schnittstelle zwischen Chemie und Biologie zu schaffen. Das Forschungsprogramm der KoRS-CB stützt sich auf enge Kooperationen zwischen den Konstanzer Fachbereichen Biologie, Chemie und Informatik & Informationswissenschaft. Dieses interdisziplinäre Konzept hat signifikant an Momentum gewonnen und sich gegenseitig befruchtende Ansätze, um zelluläre Prozesse auf molekularer Ebene verstehen zu können, entwickelt. Das Curriculum der KoRS-CB zielt darauf ab, ihre Promovierenden mit aktuellen Forschungsthemen in einem interdisziplinären Ansatz vertraut zu machen und ihnen die Kompetenz zu vermitteln, komplexe biologische Prozesse auf molekularer Ebene zu verstehen und experimentell anzugehen. Dies versetzt die Promovierenden in die Lage, eine erfolgreiche Laufbahn in akademischen oder industriellen Einrichtungen einzuschlagen. Das Trainingsprogramm der KoRS-CB, das auf dem 2002 geschaffenen und von den Fachbereichen Chemie und Biologie gemeinsam getragenen Studiengang Life Science (Bachelor/Master) beruht, wird laufend weiterentwickelt, um konzeptionellen und technologischen Neuerungen und den stetig steigenden Ansprüchen hinsichtlich wissenschaftlicher Fertigkeiten und sog. Schlüsselqualifikationen gerecht zu werden. Zusammengefasst haben das Forschungs- und Ausbildungsprogramm der KoRS-CB in Kombination mit einer zunehmenden Integration von international renommierten Forschungsstätten die Universität Konstanz als ein national und international ausgewiesenes Zentrum für Chemische Biologie platziert.

Link zum Abschlussbericht

https://dx.doi.org/10.2314/KXP:1698291612

Projektbezogene Publikationen (Auswahl)

• Enzymatic Synthesis of Multiple Spin-Labeled DNA. Angew. Chem. Int. Ed. 2008, 47, 6782-6785
  S. Obeid M. Yulikov G. Jeschke A. Marx
  
• A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nature Medicine 2009, 15, 781-787
  T. Muchamuel M. Basler M.A. Aujay E. Suzuki K.W. Kalim C. Lauer C. Sylvain E.R. Ring J. Shields J. Jiang P. Shwonek F. Parlati S.D. Demo M.K. Bennett C.J. Kirk M. Groettrup
  
• Artificial ribozyme switches containing natural riboswitch aptamer domains. Angew. Chem. Int. Ed. 2009, 48, 2715-2718
  M. Wieland A. Benz B. Klauser J.S. Hartig
  
• BTB-1: A small molecule inhibitor of the mitotic motor protein Kif18A. Angew. Chem. Int. Ed. 2009, 48, 9072-9076
  M. Catarinella T. Grüner T. Strittmatter A. Marx T.U. Mayer
  
• Human Telomeric Quadruplex Conformations Studied by Pulsed EPR. Angew. Chem. Int. Ed. 2009, 48, 9728-9730
  S. Vijay M. Azarkh T.E. Exner J.S. Hartig M. Drescher
  
• Investigation of mRNA quadruplex formation in Escherichia coli. Nature Protocols 2009, 4, 1632-1640
  M. Wieland J.S. Hartig
  
• Small-Molecule-Dependent Regulation of Transfer RNA in Bacteria. Angew. Chem. Int. Ed. 2009, 48, 7564-7567
  B. Berschneider M. Wieland M. Rubini J.S. Hartig
  
• Total Syntheses of Cytotoxic, Naturally Occurring Kalasinamide, Geovanine, and Marcanine A. Angew. Chem. Int. Ed. 2009, 48, 911-913
  S. Lang U. Groth
  
• A Highly Active DNA Polymerase with a Fluorous Core. Angew. Chem. Int. Ed. 2010, 49, 1324-1327
  B. Holzberger M. Rubini H.M. Möller A. Marx
  
• Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy. PNAS 2010, 107, 9111- 9116
  C. Eichmann S. Preissler R. Riek E. Deuerling
  
• Replacing 32 Proline Residues by a Noncanonical Amino Acid Results in a Highly Active DNA Polymerase. J. Am. Chem. Soc. 2010, 132, 15708-15713
  B. Holzberger A. Marx
  
• Replication through an abasic DNA lesion: structural basis for adenine selectivity. EMBO Journal 2010, 29, 1738-1747
  S. Obeid N. Blatter R. Kranaster A. Schnur K. Diederichs W. Welte A. Marx
  
• Structural basis for the synthesis of nucleobase modified DNA polymerase. PNAS 2010, 107, 21327-21331
  S. Obeid A. Baccaro W. Welte K. Diederichs A. Marx
  
• Structures of DNA polymerases caught processing sizeaugmented nucleotide probes. Angew. Chem. Int. Ed. 2010, 49, 5181-5184
  K. Betz F. Streckenbach A. Schnur T.E. Exner W. Welte K. Diederichs A. Marx
  
• Synthesis of defined ubiquitin dimers. J. Am. Chem. Soc. 2010, 132, 16337-16339
  S. Eger M. Scheffner A. Marx M. Rubini
  
• Emulsion Polymerization of Styrene and Methyl Methacrylate Using Cationic Switchable Surfactants. Macromolecules 2011, 44, 2501-2509
  C.I. Fowler C.M. Muchemu R.E. Miller L. Phan C. O’Neill P.G. Jessop M.F. Cunningham
  
• Polymerization Catalyst Laser- Interference Patterning. Angew. Chem. Int. Ed. 2011, 50, 9665-9667
  J. Huber B. Scheinhardt T. Geldhauser J. Boneberg S. Mecking
  
• Small-Molecule-Triggered Manipulation of DNA Three-Way Junctions. J. Am. Chem. Soc. 2011, 133, 4706-4709
  I.T. Seemann V. Singh M. Azarkh M. Drescher J.S. Hartig
  
• Barcode-modifizierte Nukleotide. Angew. Chem. Int. Ed. 2012, 51, 254-257
  A. Baccaro A.-L. Steck A. Marx
  
• Immuno- and constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity. Cell 2012, 148, 727-738
  E. M. Huber M. Basler R. Schwab W. Heinemeyer C.J. Kirk M. Groettrup M. Groll
  
• KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nature Chem. Biol. 2012, 8, 612-614
  K. Betz D.A. Malyshev T. Lavergne W. Welte K. Diederichs T.J. Dwyer P. Ordoukhanian F.E. Romesberg A. Marx
  
• Structural insights into the potential of 4-fluoroproline to modulate biophysical properties of proteins. Chem. Sci. 2012, 3, 2924-2931
  B. Holzberger S. Obeid W. Welte K. Diederichs A. Marx
  
• Structures of KlenTaq DNA Polymerase Caught While Incorporating C5-Modified Pyrimidine and C7-Modified 7- Deazapurine Nucleoside Triphosphates. J. Am. Chem. Soc. 2012, 134, 11840-11843
  K. Bergen A.-L. Steck S. Strütt A. Baccaro W. Welte K. Diederichs A. Marx
  
• A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nature Chem. Biol. 2013, 9, 491-493
  J. Gisin A. Schneider B. Nägele M. Borisova C. Mayer
  
• Combined Directed Metalation - Suzuki-Miyaura Cross Coupling Strategies. Synthesis of Isomeric Chromenopyridinones and Related Annulated Analogues. ChemInform 2013, 44, 18
  R.E. Miller R. Sommer H. Fan V. Snieckus U. Groth
  
• Fingerprinting Differential Active Site Constraints of ATPases. Chem. Sci. 2013, 4, 1588-1596
  S.M. Hacker N. Hardt A. Buntru D. Pagliarini M.M. Möckel T.U. Mayer M. Scheffner C.R. Hauck A. Marx
  
• Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption: Observing Ubiquitin Activation in Real Time. Angew. Chem. Int. Ed. 2013, 52, 11916-11919
  S.M. Hacker D. Pagliarini T. Tischer N. Hardt D. Schneider M. Mex T.U. Mayer M. Scheffner A. Marx
  
• Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins. Cell 2013, 152, 5, 1184- 1194
  J. A. Nathan V. Spinnenhirn G. Schmidtke M. Basler M. Groettrup A.L. Goldberg
  
• Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nature Commun. 2013, 4, 2993
  W.K. Min C. Bruhn P. Grigaravicius Z.W. Zhou F. Li A. Krüger B. Siddeek K.O. Greulich O. Popp C. Meisezahl C.F. Calkhoven A. Bürkle X. Xu Z.Q. Wang
  
• Red-Light-Controlled Protein- RNA Crosslinking with a Genetically Encoded Furan. Angew. Chem. Int. Ed. 2013, 52, 4690-4693
  M. Schmidt D. Summerer
  
• Site-directed spin-labeling of nucleotides and the use of incell EPR to determine longrange distances in a biologically relevant environment. Nature Protocols 2013, 8, 131-147
  M. Azarkh V. Singh O. Okle I.T. Seemann D.R. Dietrich J. S. Hartig M. Drescher
  
• Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides. J. Am. Chem. Soc. 2013, 135, 42, 15667-9
  S. Obeid H. Bußkamp W. Welte K. Diederichs A. Marx
  
• Structural insights into DNA replication without hydrogen bonds. J. Am. Chem. Soc. 2013, 135, 49, 18637-43
  K. Betz D.A. Malyshev T. Lavergne W. Welte K. Diederichs F.E. Romesberg A. Marx
  
• Structure and function of an RNA-reading thermostable DNA polymerase. Angew. Chem. Int. Ed. 2013, 52, 11935-11939
  N. Blatter K. Bergen O. Nolte W. Welte K. Diederichs K. Mayer M. Wieland A. Marx
  
• The nascent polypeptideassociated complex is a key regulator of proteostasis. EMBO Journal 2013, 32, 10, 1451-1468
  J. Kirstein-Miles A. Scior E. Deuerling R.I. Morimoto
  
• Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry. Angew. Chem. Int. Ed. 2013, 52, 4265-4268
  A. Niederwieser A.-K. Späte L.D. Nguyen C. Jüngst W. Reutter V. Wittmann
  
• A genetically encoded spin label for EPR distance measurements. J. Am. Chem. Soc. 2014, 136, 4, 1238-1241
  M.J. Schmidt J. Borbas M. Drescher D. Summerer
  
• Chain terminating and clickable NAD+ analogues for labeling target proteins of ADP- ribosyltransferases. Angew. Chem. Int. Ed. 2014, 53, 8159-8162
  Y. Wang D. Rösner M. Grzywa A. Marx
  
• Direct Sensing of 5- Methylcytosine by Polymerase Chain Reaction. Angew. Chem. Int. Ed. 2014, 53, 31, 8154-8158,
  J. Aschenbrenner M. Drum H. Topal M. Wieland A. Marx
  
• Dissecting ubiquitin signaling by linkage-defined and protease resistant ubiquitin chains. Angew. Chem. Int. Ed. 2014, 53, 47, 12925-12929
  T. Schneider D. Schneider D. Rösner S. Malhotra F. Mortensen T.U. Mayer M. Scheffner A. Marx
  
• Gd(III)-PyMTA Label Is Suitable for In-Cell EPR. J. Am. Chem. Soc. 2014, 136, 43, 15366-15378
  M. Qi A. Groß G. Jeschke A. Godt M. Drescher
  
• Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO Molecular Medicine 2014, 6, 5, 569-703
  M. Basler S. Mundt T. Muchamuel C. Moll J. Jiang M. Groettrup C.J. Kirk
  
• Modulating the pKa of a tyrosine in KlenTaq DNA polymerase that is crucial for abasic site bypass by in vivo incorporation of a noncanonical amino acid. ChemBioChem 2014, 15, 1735-1737
  N. Blatter A. Prokup A. Deiters A. Marx
  
• Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A. Nature Commun. 2014, 5, 4397
  J. Häfner M.I. Mayr M.M. Möckel T.U. Mayer
  
• Programmable and highly resolved in vitro detection of genomic 5-methylcytosine by TALEs Angew. Chem. Int. Ed. 2014, 53, 23, 6002-6006
  G. Kubik M.J. Schmidt J.E. Penner D. Summerer
  
• Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit. Angew. Chem. Int. Ed. 2014, 53, 10247-10250
  S. M. Hacker F. Mortensen M. Scheffner A. Marx
  
• Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle. Nature 2014, 507, 114-117
  K. Denger M. Weiss A.-K. Felux A. Schneider C. Mayer D. Spiteller T. Huhn A.M. Cook D. Schleheck
  
• Synthetic Polyester from Algae Oil. Angew. Chem. Int. Ed. 2014 53, 26, 6800-6804
  P. Roesle F. Stempfle S.K. Hess J. Zimmerer C. R. Bártulos B. Lepetit A. Eckert P.G. Kroth S. Mecking
  
• An Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1. PNAS 2015, 112, 31, E4298-E4305
  A.-K. Felux D. Spiteller J. Klebensberger D. Schleheck
  
• Chorismatase Mechanisms Reveal Fundamentally Different Types of Reaction in a Single Conserved Protein Fold. J. Am. Chem. Soc. 2015, 137, 34, 11032-11037
  F. Hubrich P. Juneja M. Müller K. Diederichs W. Welte J.N. Andexer
  
• Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation. Nature Protocols 2015, 10, 10, 1594-1611
  D. Rösner T. Schneider D. Schneider M. Scheffner A. Marx
  
• DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplexderived DNAzyme. Chem. Commun. 2015, 51, 7379-7381
  D. Verga M. Welter A.-L. Steck A. Marx
  
• Not4-dependent translational repression is important for cellular protein homeostasis in yeast. EMBO Journal 2015, 34, 12
  S. Preissler J. Reuther M. Koch A. Scior M. Bruderek T. Frickey E. Deuerling
  
• Programmable Sensors of 5- Hydroxymethylcytosine. J. Am. Chem. Soc. 2015, 137, 1, 2-5
  G. Kubik S. Batke D. Summerer
  
• Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit. EMBO Reports 2015, 16, 11, 1501-1510
  A. Heim A. Konietzny T.U. Mayer
  
• Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination. PNAS 2015, 112, 32, 9872-9877
  F. Mortensen D. Schneider T. Barbic A. Sladewska- Marquardt S. Kühnle A. Marx M. Scheffner
  
• The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum. Science 2015, 348, 6231, 201-207
  M. Gamerdinger M.A. Hanebuth T. Frickey E. Deuerling
  
• A cascading activity-based probe sequentially targets E1– E2–E3 ubiquitin enzymes. Nature Chem. Biol. 2016, 12, 7, 523-530
  M.P.C. Mulder K. Witting I. Berlin J. N. Pruneda K.-P. Wu J.-G. Chang J. Bialas M. Groettrup F. El Oualid H. Ovaa
  
• Bioorthogonally Functionalized NAD+ Analogues for In-Cell Visualization of Poly(ADP- Ribose) Formation. Angew. Chem. Int. Ed. 2016, 55, 27, 7660-7664
  S. Wallrodt A. Buntz Y. Wang A. Zumbusch A. Marx
  
• Designer Extracellular Matrix Based on DNA-Peptide Networks Generated by Polymerase Chain Reaction. Angew. Chem. Int. Ed. 2016, 55, 34, 10136-10140
  A. Finke H. Bußkamp M. Manea A. Marx
  
• Modified Nucleotides for Discrimination between Cytosine and the Epigenetic Marker 5-Methylcytosine. Angew. Chem. Int. Ed. 2016, 55, 9, 3229-3232
  J. von Watzdorf K. Leitner A. Marx
  
• Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction. Nature Commun. 2016, 7, 13695
  M.A. Hanebuth R. Kityk S.J. Fries A. Jain A. Kriel V. Albanese T. Frickey C. Peter M.P. Mayer J. Frydman E. Deuerling
  
• Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation. Angew. Chem. Int. Ed. 2016, 55, 27, 11256-11260
  A. Buntz S. Wallrodt E.C. Gwosch M. Schmalz S. Beneke E. Ferrando-May A. Marx A. Zumbusch
  
• Sequence-Specific Incorporation of Enzyme- Nucleotide Chimera by DNA Polymerases. Angew. Chem. Int. Ed. 2016, 55, 10131-10135
  M. Welter D. Verga A. Marx
  
• Twister ribozymes as highly versatile expression platforms for artificial riboswitches. Nature Commun. 2016, 7, 12834
  M. Felletti J. Stifel L.A. Wurmthaler S. Geiger J.S. Hartig
  
• Visualization of Protein-Specific Glycosylation inside Living Cells. Angew. Chem. Int. Ed. 2016, 55, 6, 2262-2266
  F. Doll A. Buntz A.-K. Späte V.F. Schart A. Timper W. Schrimpf C.R. Hauck A. Zumbusch V. Wittmann
  
• Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding. J. Am. Chem. Soc. 2017, 139, 12, 4254-4257
  M. Robotta J. Cattani J.C. Martins V. Subramaniam M. Drescher
  
• Identification of Proteins Interacting with Ubiquitin Chains. Angew. Chem. Int. Ed. 2017, 56, 15764-15768
  X. Zhao J. Lutz E. Höllmüller M. Scheffner A. Marx F. Stengel
  
• Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues. Beilstein J. Org. Chem. 2017, 13, 495-501
  S. Wallrodt E.L. Simpson A. Marx
  
• Plastid thylakoid architecture optimizes photosynthesis in diatoms. Nature Commun. 2017, 8, 15885
  S. Flori P.H. Jouneau B. Bailleul B. Gallet L.F. Estrozi C. Moriscot O. Bastien S. Eicke A.F. Schober C. Río Bártulos E. Maréchal P.G. Kroth D. Petroutsos S. Zeeman C. Breyton G. Schoehn D. Falconet G. Finazzi
  
• Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of a complexes for apoptosis regulation Nature Commun. 2017, 8, 1, 73
  S. Bleicken A. Hantusch K.K. Das T. Frickey A.J. Garcia-Saez
  
• Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair. Angew. Chem. Int. Ed. 2017, 56, 39, 12000-12003
  K. Betz M. Kimoto K. Diederichs I. Hirao A. Marx
  
• Valorization of Unconventional Lipids from Microalgae or Tall Oil via a Selective Dual Catalysis One-Pot Approach. J. Am. Chem. Soc. 2017, 139, 38, 13487-13491
  S.K. Hess N.S. Schunck V. Goldbach D. Ewe P.G. Kroth S. Mecking
  
• Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20. EMBO Reports 2018, 19, 12
  A. Heim T. Tischer T.U. Mayer
  
• Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Reports 2018, 19, 12, pii: e46512
  M. Basler M.M. Lindstrom J.J. LaStant J.M. Bradshaw T.D. Owens C. Schmidt E. Maurits C. Tsu H.S. Overkleeft C.J. Kirk C.L. Langrish M. Groettrup
  
• Engineering of a DNA Polymerase for Direct m(6) A Sequencing. Angew. Chem. Int. Ed. 2018, 57, 2, 417-421
  J. Aschenbrenner S. Werner V. Marchand M. Adam Y. Motorin M. Helm A. Marx
  
• Snapshots of a modified nucleotide moving through the confines of a DNA polymerase. PNAS 2018, 115, 40, 9992- 9997
  H.M. Kropp S.L. Durr C. Peter K. Diederichs A. Marx
  
• Structural dynamics of the E6AP/UBE3A-E6-p53 enzymesubstrate complex. Nature Commun. 2018, 9, 4441
  C. Sailer F. Offensperger A. Julier K.-M. Kammer R. Walker-Gray M.G. Gold M. Scheffner F. Stengel
  
• The structure of the ubiquitinlike modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nature Commun. 2018, 9, 1, 3321
  A. Aichem S. Anders N. Catone P. Rossler S. Stotz A. Berg R. Schwab S. Scheuermann J. Bialas M.C. Schutz-Stoffregen G. Schmidtke C. Peter M. Groettrup S. Wiesner
  
• Widespread bacterial lysine degradation proceeding via glutarate and L-2- hydroxyglutarate. Nature Commun. 2018, 9, 1, 5071
  S. Knorr M. Sinn D. Galetskiy R.M. Williams C. Wang N. Müller O. Mayans D. Schleheck J.S. Hartig
  
• A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia. PNAS 2019, 116, 8, 3171-3176
  S.C. Peck K. Denger A. Burrichter S.M. Irwin E.P. Balskus D. Schleheck
  
• A tetracycline-dependent ribozyme switch allows conditional induction of gene expression in Caenorhabditis elegans. Nature Commun. 2019, 10, 1, 491
  L.A. Wurmthaler M. Sack K. Gense J.S. Hartig M. Gamerdinger
  
• Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies. Mol. Cell 2019, 74, 4, 729- 741.e7
  K. Shen M. Gamerdinger R. Chan K. Gense E.M. Martin N. Sachs P.D. Knight R. Schlomer A.N. Calabrese K.L. Stewart L. Leiendecker A. Baghel S.E. Radford J. Frydman E. Deuerling
  
• Pyrite formation from FeS and H2S is mediated through microbial redox activity. PNAS 2019, 116, 14, 6897- 6902
  J. Thiel J.M. Byrne A. Kappler B. Schink M. Pester
  
• The Structure of an Archaeal B- Family DNA Polymerase in Complex with a Chemically Modified Nucleotide. Angew. Chem. Int. Ed. 2019, 58, 16, 5457-5461
  H.M. Kropp K. Diederichs A. Marx