GSC 218:  Konstanz Research School Chemical Biology (KoRS-CB)

• Subject Area: Basic Research in Biology and Medicine ; Biological Chemistry and Food Chemistry ; Microbiology, Virology and Immunology
• Term: from 2007 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 39072414

• Final Report Year: 2019

Final Report Abstract

The elucidation of the intricate network of molecular interactions that govern physiological processes at the cellular and systemic level has become a major focus of basic and applied research. This fascinating, yet challenging task requires that multiple scientific disciplines unite to create new synergistic interdisciplinary approaches. Indeed, there is an increasing demand in academia, research institutions, and industry for scientists who are trained at the interface of Chemistry and Biology. Thus, the interdisciplinary Konstanz Research School for Chemical Biology (KoRS-CB) was established to provide the optimal education and training for young scientists working at the intersection of chemistry and biology. To foster training beyond the limits of traditional disciplines, the KoRS-CB research programme is based on intimate collaborative research efforts within and between the Departments of Biology, Chemistry, and Computer & Information Science at the University of Konstanz. This interdisciplinary concept has significantly gained momentum and culminated to research activities that develop novel mutually illuminating approaches for an increased understanding of cellular processes at the molecular and atomic level. The curriculum of KoRS-CB familiarizes its doctoral fellows with prevailing fields of research by exchanging methods, principles, and concepts. This training provides doctoral researchers with a strong interdisciplinary foundation that will enable them to understand and experimentally approach complex cellular processes and, thus, to pursue a successful career in academia or industry. The doctoral training programme of KoRS-CB that builds on the Bachelor/Master study course Life Science - established in 2002 and jointly supported by the Departments of Chemistry and Biology - is continuously refined to adjust the education of the next generations of researchers to conceptual and technological developments and increasing demands in scientific and transferable skills. In summary, KoRS-CB is a key element of the interdisciplinary research and training priority focus on Chemical Biology at the University of Konstanz. Further advances of the research and training programme combined with increasing integration of internationally renowned research institutes placed the University of Konstanz as a nationally and internationally recognized centre for Chemical Biology.

Link to the final report

https://dx.doi.org/10.2314/KXP:1698291612

Publications

• Enzymatic Synthesis of Multiple Spin-Labeled DNA. Angew. Chem. Int. Ed. 2008, 47, 6782-6785
  S. Obeid M. Yulikov G. Jeschke A. Marx
  (See online at https://doi.org/10.1002/anie.200802314)
• A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nature Medicine 2009, 15, 781-787
  T. Muchamuel M. Basler M.A. Aujay E. Suzuki K.W. Kalim C. Lauer C. Sylvain E.R. Ring J. Shields J. Jiang P. Shwonek F. Parlati S.D. Demo M.K. Bennett C.J. Kirk M. Groettrup
  (See online at https://doi.org/10.1038/nm.1978)
• Artificial ribozyme switches containing natural riboswitch aptamer domains. Angew. Chem. Int. Ed. 2009, 48, 2715-2718
  M. Wieland A. Benz B. Klauser J.S. Hartig
  (See online at https://doi.org/10.1002/anie.200805311)
• BTB-1: A small molecule inhibitor of the mitotic motor protein Kif18A. Angew. Chem. Int. Ed. 2009, 48, 9072-9076
  M. Catarinella T. Grüner T. Strittmatter A. Marx T.U. Mayer
  (See online at https://doi.org/10.1002/anie.200904510)
• Human Telomeric Quadruplex Conformations Studied by Pulsed EPR. Angew. Chem. Int. Ed. 2009, 48, 9728-9730
  S. Vijay M. Azarkh T.E. Exner J.S. Hartig M. Drescher
  (See online at https://doi.org/10.1002/anie.200902146)
• Investigation of mRNA quadruplex formation in Escherichia coli. Nature Protocols 2009, 4, 1632-1640
  M. Wieland J.S. Hartig
  (See online at https://doi.org/10.1038/nprot.2009.111)
• Small-Molecule-Dependent Regulation of Transfer RNA in Bacteria. Angew. Chem. Int. Ed. 2009, 48, 7564-7567
  B. Berschneider M. Wieland M. Rubini J.S. Hartig
  (See online at https://doi.org/10.1002/anie.200900851)
• Total Syntheses of Cytotoxic, Naturally Occurring Kalasinamide, Geovanine, and Marcanine A. Angew. Chem. Int. Ed. 2009, 48, 911-913
  S. Lang U. Groth
  (See online at https://doi.org/10.1002/anie.200804388)
• A Highly Active DNA Polymerase with a Fluorous Core. Angew. Chem. Int. Ed. 2010, 49, 1324-1327
  B. Holzberger M. Rubini H.M. Möller A. Marx
  (See online at https://doi.org/10.1002/anie.200905978)
• Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy. PNAS 2010, 107, 9111- 9116
  C. Eichmann S. Preissler R. Riek E. Deuerling
  (See online at https://doi.org/10.1073/pnas.0914300107)
• Replacing 32 Proline Residues by a Noncanonical Amino Acid Results in a Highly Active DNA Polymerase. J. Am. Chem. Soc. 2010, 132, 15708-15713
  B. Holzberger A. Marx
  (See online at https://doi.org/10.1021/ja106525y)
• Replication through an abasic DNA lesion: structural basis for adenine selectivity. EMBO Journal 2010, 29, 1738-1747
  S. Obeid N. Blatter R. Kranaster A. Schnur K. Diederichs W. Welte A. Marx
  (See online at https://doi.org/10.1038/emboj.2010.64)
• Structural basis for the synthesis of nucleobase modified DNA polymerase. PNAS 2010, 107, 21327-21331
  S. Obeid A. Baccaro W. Welte K. Diederichs A. Marx
  (See online at https://doi.org/10.1073/pnas.1013804107)
• Structures of DNA polymerases caught processing sizeaugmented nucleotide probes. Angew. Chem. Int. Ed. 2010, 49, 5181-5184
  K. Betz F. Streckenbach A. Schnur T.E. Exner W. Welte K. Diederichs A. Marx
  (See online at https://doi.org/10.1002/anie.200905724)
• Synthesis of defined ubiquitin dimers. J. Am. Chem. Soc. 2010, 132, 16337-16339
  S. Eger M. Scheffner A. Marx M. Rubini
  (See online at https://doi.org/10.1021/ja1072838)
• Emulsion Polymerization of Styrene and Methyl Methacrylate Using Cationic Switchable Surfactants. Macromolecules 2011, 44, 2501-2509
  C.I. Fowler C.M. Muchemu R.E. Miller L. Phan C. O’Neill P.G. Jessop M.F. Cunningham
  (See online at https://doi.org/10.1021/ma102936a)
• Polymerization Catalyst Laser- Interference Patterning. Angew. Chem. Int. Ed. 2011, 50, 9665-9667
  J. Huber B. Scheinhardt T. Geldhauser J. Boneberg S. Mecking
  (See online at https://doi.org/10.1002/anie.201103990)
• Small-Molecule-Triggered Manipulation of DNA Three-Way Junctions. J. Am. Chem. Soc. 2011, 133, 4706-4709
  I.T. Seemann V. Singh M. Azarkh M. Drescher J.S. Hartig
  (See online at https://doi.org/10.1021/ja110986u)
• Barcode-modifizierte Nukleotide. Angew. Chem. Int. Ed. 2012, 51, 254-257
  A. Baccaro A.-L. Steck A. Marx
  (See online at https://doi.org/10.1002/ange.201105717)
• Immuno- and constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity. Cell 2012, 148, 727-738
  E. M. Huber M. Basler R. Schwab W. Heinemeyer C.J. Kirk M. Groettrup M. Groll
  (See online at https://doi.org/10.1016/j.cell.2011.12.030)
• KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nature Chem. Biol. 2012, 8, 612-614
  K. Betz D.A. Malyshev T. Lavergne W. Welte K. Diederichs T.J. Dwyer P. Ordoukhanian F.E. Romesberg A. Marx
  (See online at https://doi.org/10.1038/NCHEMBIO.966)
• Structural insights into the potential of 4-fluoroproline to modulate biophysical properties of proteins. Chem. Sci. 2012, 3, 2924-2931
  B. Holzberger S. Obeid W. Welte K. Diederichs A. Marx
  (See online at https://doi.org/10.1039/c2sc20545a)
• Structures of KlenTaq DNA Polymerase Caught While Incorporating C5-Modified Pyrimidine and C7-Modified 7- Deazapurine Nucleoside Triphosphates. J. Am. Chem. Soc. 2012, 134, 11840-11843
  K. Bergen A.-L. Steck S. Strütt A. Baccaro W. Welte K. Diederichs A. Marx
  (See online at https://doi.org/10.1021/ja3017889)
• A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nature Chem. Biol. 2013, 9, 491-493
  J. Gisin A. Schneider B. Nägele M. Borisova C. Mayer
  (See online at https://doi.org/10.1038/nchembio.1289)
• Combined Directed Metalation - Suzuki-Miyaura Cross Coupling Strategies. Synthesis of Isomeric Chromenopyridinones and Related Annulated Analogues. ChemInform 2013, 44, 18
  R.E. Miller R. Sommer H. Fan V. Snieckus U. Groth
  (See online at https://doi.org/10.3987/COM-12-S(N)131)
• Fingerprinting Differential Active Site Constraints of ATPases. Chem. Sci. 2013, 4, 1588-1596
  S.M. Hacker N. Hardt A. Buntru D. Pagliarini M.M. Möckel T.U. Mayer M. Scheffner C.R. Hauck A. Marx
  (See online at https://doi.org/10.1039/c3sc21916j)
• Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption: Observing Ubiquitin Activation in Real Time. Angew. Chem. Int. Ed. 2013, 52, 11916-11919
  S.M. Hacker D. Pagliarini T. Tischer N. Hardt D. Schneider M. Mex T.U. Mayer M. Scheffner A. Marx
  (See online at https://doi.org/10.1002/anie.201304723)
• Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins. Cell 2013, 152, 5, 1184- 1194
  J. A. Nathan V. Spinnenhirn G. Schmidtke M. Basler M. Groettrup A.L. Goldberg
  (See online at https://doi.org/10.1016/j.cell.2013.01.037)
• Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nature Commun. 2013, 4, 2993
  W.K. Min C. Bruhn P. Grigaravicius Z.W. Zhou F. Li A. Krüger B. Siddeek K.O. Greulich O. Popp C. Meisezahl C.F. Calkhoven A. Bürkle X. Xu Z.Q. Wang
  (See online at https://doi.org/10.1038/ncomms3993)
• Red-Light-Controlled Protein- RNA Crosslinking with a Genetically Encoded Furan. Angew. Chem. Int. Ed. 2013, 52, 4690-4693
  M. Schmidt D. Summerer
  (See online at https://doi.org/10.1002/anie.201300754)
• Site-directed spin-labeling of nucleotides and the use of incell EPR to determine longrange distances in a biologically relevant environment. Nature Protocols 2013, 8, 131-147
  M. Azarkh V. Singh O. Okle I.T. Seemann D.R. Dietrich J. S. Hartig M. Drescher
  (See online at https://doi.org/10.1038/nprot.2012.136)
• Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides. J. Am. Chem. Soc. 2013, 135, 42, 15667-9
  S. Obeid H. Bußkamp W. Welte K. Diederichs A. Marx
  (See online at https://doi.org/10.1021/ja405346s)
• Structural insights into DNA replication without hydrogen bonds. J. Am. Chem. Soc. 2013, 135, 49, 18637-43
  K. Betz D.A. Malyshev T. Lavergne W. Welte K. Diederichs F.E. Romesberg A. Marx
  (See online at https://doi.org/10.1021/ja409609j)
• Structure and function of an RNA-reading thermostable DNA polymerase. Angew. Chem. Int. Ed. 2013, 52, 11935-11939
  N. Blatter K. Bergen O. Nolte W. Welte K. Diederichs K. Mayer M. Wieland A. Marx
  (See online at https://doi.org/10.1002/anie.201306655)
• The nascent polypeptideassociated complex is a key regulator of proteostasis. EMBO Journal 2013, 32, 10, 1451-1468
  J. Kirstein-Miles A. Scior E. Deuerling R.I. Morimoto
  (See online at https://doi.org/10.1038/emboj.2013.87)
• Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry. Angew. Chem. Int. Ed. 2013, 52, 4265-4268
  A. Niederwieser A.-K. Späte L.D. Nguyen C. Jüngst W. Reutter V. Wittmann
  (See online at https://doi.org/10.1002/anie.201208991)
• A genetically encoded spin label for EPR distance measurements. J. Am. Chem. Soc. 2014, 136, 4, 1238-1241
  M.J. Schmidt J. Borbas M. Drescher D. Summerer
  (See online at https://doi.org/10.1021/ja411535q)
• Chain terminating and clickable NAD+ analogues for labeling target proteins of ADP- ribosyltransferases. Angew. Chem. Int. Ed. 2014, 53, 8159-8162
  Y. Wang D. Rösner M. Grzywa A. Marx
  (See online at https://doi.org/10.1002/anie.201404431)
• Direct Sensing of 5- Methylcytosine by Polymerase Chain Reaction. Angew. Chem. Int. Ed. 2014, 53, 31, 8154-8158,
  J. Aschenbrenner M. Drum H. Topal M. Wieland A. Marx
  (See online at https://doi.org/10.1002/anie.201403745)
• Dissecting ubiquitin signaling by linkage-defined and protease resistant ubiquitin chains. Angew. Chem. Int. Ed. 2014, 53, 47, 12925-12929
  T. Schneider D. Schneider D. Rösner S. Malhotra F. Mortensen T.U. Mayer M. Scheffner A. Marx
  (See online at https://doi.org/10.1002/anie.201407192)
• Gd(III)-PyMTA Label Is Suitable for In-Cell EPR. J. Am. Chem. Soc. 2014, 136, 43, 15366-15378
  M. Qi A. Groß G. Jeschke A. Godt M. Drescher
  (See online at https://doi.org/10.1021/ja508274d)
• Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO Molecular Medicine 2014, 6, 5, 569-703
  M. Basler S. Mundt T. Muchamuel C. Moll J. Jiang M. Groettrup C.J. Kirk
  (See online at https://doi.org/10.1002/emmm.201303543)
• Modulating the pKa of a tyrosine in KlenTaq DNA polymerase that is crucial for abasic site bypass by in vivo incorporation of a noncanonical amino acid. ChemBioChem 2014, 15, 1735-1737
  N. Blatter A. Prokup A. Deiters A. Marx
  (See online at https://doi.org/10.1002/cbic.201400051)
• Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A. Nature Commun. 2014, 5, 4397
  J. Häfner M.I. Mayr M.M. Möckel T.U. Mayer
  (See online at https://doi.org/10.1038/ncomms5397)
• Programmable and highly resolved in vitro detection of genomic 5-methylcytosine by TALEs Angew. Chem. Int. Ed. 2014, 53, 23, 6002-6006
  G. Kubik M.J. Schmidt J.E. Penner D. Summerer
  (See online at https://doi.org/10.1002/anie.201400436)
• Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit. Angew. Chem. Int. Ed. 2014, 53, 10247-10250
  S. M. Hacker F. Mortensen M. Scheffner A. Marx
  (See online at https://doi.org/10.1002/anie.201405259)
• Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle. Nature 2014, 507, 114-117
  K. Denger M. Weiss A.-K. Felux A. Schneider C. Mayer D. Spiteller T. Huhn A.M. Cook D. Schleheck
  (See online at https://doi.org/10.1038/nature12947)
• Synthetic Polyester from Algae Oil. Angew. Chem. Int. Ed. 2014 53, 26, 6800-6804
  P. Roesle F. Stempfle S.K. Hess J. Zimmerer C. R. Bártulos B. Lepetit A. Eckert P.G. Kroth S. Mecking
  (See online at https://doi.org/10.1002/anie.201403991)
• An Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1. PNAS 2015, 112, 31, E4298-E4305
  A.-K. Felux D. Spiteller J. Klebensberger D. Schleheck
  (See online at https://doi.org/10.1073/pnas.1507049112)
• Chorismatase Mechanisms Reveal Fundamentally Different Types of Reaction in a Single Conserved Protein Fold. J. Am. Chem. Soc. 2015, 137, 34, 11032-11037
  F. Hubrich P. Juneja M. Müller K. Diederichs W. Welte J.N. Andexer
  (See online at https://doi.org/10.1021/jacs.5b05559)
• Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation. Nature Protocols 2015, 10, 10, 1594-1611
  D. Rösner T. Schneider D. Schneider M. Scheffner A. Marx
  (See online at https://doi.org/10.1038/nprot.2015.106)
• DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplexderived DNAzyme. Chem. Commun. 2015, 51, 7379-7381
  D. Verga M. Welter A.-L. Steck A. Marx
  (See online at https://doi.org/10.1039/c5cc01387a)
• Not4-dependent translational repression is important for cellular protein homeostasis in yeast. EMBO Journal 2015, 34, 12
  S. Preissler J. Reuther M. Koch A. Scior M. Bruderek T. Frickey E. Deuerling
  (See online at https://doi.org/10.15252/embj.201490194)
• Programmable Sensors of 5- Hydroxymethylcytosine. J. Am. Chem. Soc. 2015, 137, 1, 2-5
  G. Kubik S. Batke D. Summerer
  (See online at https://doi.org/10.1021/ja506022t)
• Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit. EMBO Reports 2015, 16, 11, 1501-1510
  A. Heim A. Konietzny T.U. Mayer
  (See online at https://doi.org/10.15252/embr.201540876)
• Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination. PNAS 2015, 112, 32, 9872-9877
  F. Mortensen D. Schneider T. Barbic A. Sladewska- Marquardt S. Kühnle A. Marx M. Scheffner
  (See online at https://doi.org/10.1073/pnas.1505923112)
• The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum. Science 2015, 348, 6231, 201-207
  M. Gamerdinger M.A. Hanebuth T. Frickey E. Deuerling
  (See online at https://doi.org/10.1126/science.aaa5335)
• A cascading activity-based probe sequentially targets E1– E2–E3 ubiquitin enzymes. Nature Chem. Biol. 2016, 12, 7, 523-530
  M.P.C. Mulder K. Witting I. Berlin J. N. Pruneda K.-P. Wu J.-G. Chang J. Bialas M. Groettrup F. El Oualid H. Ovaa
  (See online at https://doi.org/10.1038/nchembio.2084)
• Bioorthogonally Functionalized NAD+ Analogues for In-Cell Visualization of Poly(ADP- Ribose) Formation. Angew. Chem. Int. Ed. 2016, 55, 27, 7660-7664
  S. Wallrodt A. Buntz Y. Wang A. Zumbusch A. Marx
  (See online at https://doi.org/10.1002/anie.201600464)
• Designer Extracellular Matrix Based on DNA-Peptide Networks Generated by Polymerase Chain Reaction. Angew. Chem. Int. Ed. 2016, 55, 34, 10136-10140
  A. Finke H. Bußkamp M. Manea A. Marx
  (See online at https://doi.org/10.1002/anie.201604687)
• Modified Nucleotides for Discrimination between Cytosine and the Epigenetic Marker 5-Methylcytosine. Angew. Chem. Int. Ed. 2016, 55, 9, 3229-3232
  J. von Watzdorf K. Leitner A. Marx
  (See online at https://doi.org/10.1002/anie.201511520)
• Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction. Nature Commun. 2016, 7, 13695
  M.A. Hanebuth R. Kityk S.J. Fries A. Jain A. Kriel V. Albanese T. Frickey C. Peter M.P. Mayer J. Frydman E. Deuerling
  (See online at https://doi.org/10.1038/ncomms13695)
• Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation. Angew. Chem. Int. Ed. 2016, 55, 27, 11256-11260
  A. Buntz S. Wallrodt E.C. Gwosch M. Schmalz S. Beneke E. Ferrando-May A. Marx A. Zumbusch
  (See online at https://doi.org/10.1002/anie.201605282)
• Sequence-Specific Incorporation of Enzyme- Nucleotide Chimera by DNA Polymerases. Angew. Chem. Int. Ed. 2016, 55, 10131-10135
  M. Welter D. Verga A. Marx
  (See online at https://doi.org/10.1002/anie.201604641)
• Twister ribozymes as highly versatile expression platforms for artificial riboswitches. Nature Commun. 2016, 7, 12834
  M. Felletti J. Stifel L.A. Wurmthaler S. Geiger J.S. Hartig
  (See online at https://doi.org/10.1038/ncomms12834)
• Visualization of Protein-Specific Glycosylation inside Living Cells. Angew. Chem. Int. Ed. 2016, 55, 6, 2262-2266
  F. Doll A. Buntz A.-K. Späte V.F. Schart A. Timper W. Schrimpf C.R. Hauck A. Zumbusch V. Wittmann
  (See online at https://doi.org/10.1002/anie.201503183)
• Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding. J. Am. Chem. Soc. 2017, 139, 12, 4254-4257
  M. Robotta J. Cattani J.C. Martins V. Subramaniam M. Drescher
  (See online at https://doi.org/10.1021/jacs.6b05335)
• Identification of Proteins Interacting with Ubiquitin Chains. Angew. Chem. Int. Ed. 2017, 56, 15764-15768
  X. Zhao J. Lutz E. Höllmüller M. Scheffner A. Marx F. Stengel
  (See online at https://doi.org/10.1002/anie.201705898)
• Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues. Beilstein J. Org. Chem. 2017, 13, 495-501
  S. Wallrodt E.L. Simpson A. Marx
  (See online at https://doi.org/10.3762/bjoc.13.49)
• Plastid thylakoid architecture optimizes photosynthesis in diatoms. Nature Commun. 2017, 8, 15885
  S. Flori P.H. Jouneau B. Bailleul B. Gallet L.F. Estrozi C. Moriscot O. Bastien S. Eicke A.F. Schober C. Río Bártulos E. Maréchal P.G. Kroth D. Petroutsos S. Zeeman C. Breyton G. Schoehn D. Falconet G. Finazzi
  (See online at https://doi.org/10.1038/ncomms15885)
• Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of a complexes for apoptosis regulation Nature Commun. 2017, 8, 1, 73
  S. Bleicken A. Hantusch K.K. Das T. Frickey A.J. Garcia-Saez
  (See online at https://doi.org/10.1038/s41467-017-00086-6)
• Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair. Angew. Chem. Int. Ed. 2017, 56, 39, 12000-12003
  K. Betz M. Kimoto K. Diederichs I. Hirao A. Marx
  (See online at https://doi.org/10.1002/anie.201704190)
• Valorization of Unconventional Lipids from Microalgae or Tall Oil via a Selective Dual Catalysis One-Pot Approach. J. Am. Chem. Soc. 2017, 139, 38, 13487-13491
  S.K. Hess N.S. Schunck V. Goldbach D. Ewe P.G. Kroth S. Mecking
  (See online at https://doi.org/10.1021/jacs.7b06957)
• Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20. EMBO Reports 2018, 19, 12
  A. Heim T. Tischer T.U. Mayer
  (See online at https://doi.org/10.15252/embr.201846433)
• Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Reports 2018, 19, 12, pii: e46512
  M. Basler M.M. Lindstrom J.J. LaStant J.M. Bradshaw T.D. Owens C. Schmidt E. Maurits C. Tsu H.S. Overkleeft C.J. Kirk C.L. Langrish M. Groettrup
  (See online at https://doi.org/10.15252/embr.201846512)
• Engineering of a DNA Polymerase for Direct m(6) A Sequencing. Angew. Chem. Int. Ed. 2018, 57, 2, 417-421
  J. Aschenbrenner S. Werner V. Marchand M. Adam Y. Motorin M. Helm A. Marx
  (See online at https://doi.org/10.1002/anie.201710209)
• Snapshots of a modified nucleotide moving through the confines of a DNA polymerase. PNAS 2018, 115, 40, 9992- 9997
  H.M. Kropp S.L. Durr C. Peter K. Diederichs A. Marx
  (See online at https://doi.org/10.1073/pnas.1811518115)
• Structural dynamics of the E6AP/UBE3A-E6-p53 enzymesubstrate complex. Nature Commun. 2018, 9, 4441
  C. Sailer F. Offensperger A. Julier K.-M. Kammer R. Walker-Gray M.G. Gold M. Scheffner F. Stengel
  (See online at https://doi.org/10.1038/s41467-018-06953-0)
• The structure of the ubiquitinlike modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nature Commun. 2018, 9, 1, 3321
  A. Aichem S. Anders N. Catone P. Rossler S. Stotz A. Berg R. Schwab S. Scheuermann J. Bialas M.C. Schutz-Stoffregen G. Schmidtke C. Peter M. Groettrup S. Wiesner
  (See online at https://doi.org/10.1038/s41467-018-05776-3)
• Widespread bacterial lysine degradation proceeding via glutarate and L-2- hydroxyglutarate. Nature Commun. 2018, 9, 1, 5071
  S. Knorr M. Sinn D. Galetskiy R.M. Williams C. Wang N. Müller O. Mayans D. Schleheck J.S. Hartig
  (See online at https://doi.org/10.1038/s41467-018-07563-6)
• A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia. PNAS 2019, 116, 8, 3171-3176
  S.C. Peck K. Denger A. Burrichter S.M. Irwin E.P. Balskus D. Schleheck
  (See online at https://doi.org/10.1073/pnas.1815661116)
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