Mechanochemische Aktivierung inerter chemischer Bindungen

• Antragsteller: Professor Dr. Carsten Bolm
• Fachliche Zuordnung: Organische Molekülchemie - Synthese, Charakterisierung
• Förderung: Förderung von 2018 bis 2022
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 392103996

• Erstellungsjahr: 2022

Zusammenfassung der Projektergebnisse

In this collaborative research project with Professor Shi from Fudan University in Shanghai, China, we aimed at developing a mechanochemical approach towards protoberberine alkaloids. The solution-based strategies had proven difficult, and we now focused on solvent-free metal-catalyzed C–H-bond functionalization processes in ball mills. Facing similar difficulties as in solution, we finally succeeded in obtaining a representative product although in only very low yield. As the project proceeded, additional questions (including those related to catalytic activities of trace metals and in-situ analytical methods for mechanistic studies) became relevant, and those will now gain priority in subsequent research targets.

Projektbezogene Publikationen (Auswahl)

• The use of copper and vanadium mineral ores in catalysed mechanochemical carbon–carbon bond formations. ACS Sustainable Chem. Eng. 2020, 8, 7262–7266
  F. Puccetti, C. Schumacher, H. Wotruba, J. Hernández, C. Bolm
  
• Mechanistic Insights on the Mechanosynthesis of Phenytoin, a WHO Essential Medicine. Chem. Eur. J. 2022, 28, e202104409
  F. Puccetti, S. Lukin, K. Užarević, E. Colacino, I. Halasz, C. Bolm, J. G. Hernández