Mechanochemische Aktivierung inerter chemischer Bindungen

• Antragsteller: Professor Dr. Carsten Bolm
• Fachliche Zuordnung: Organische Molekülchemie - Synthese, Charakterisierung
• Förderung: Förderung von 2018 bis 2022
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 392103996

• Erstellungsjahr: 2022

Zusammenfassung der Projektergebnisse

In this collaborative research project with Professor Shi from Fudan University in Shanghai, China, we aimed at developing a mechanochemical approach towards protoberberine alkaloids. The solution-based strategies had proven difficult, and we now focused on solvent-free metal-catalyzed C–H-bond functionalization processes in ball mills. Facing similar difficulties as in solution, we finally succeeded in obtaining a representative product although in only very low yield. As the project proceeded, additional questions (including those related to catalytic activities of trace metals and in-situ analytical methods for mechanistic studies) became relevant, and those will now gain priority in subsequent research targets.

Projektbezogene Publikationen (Auswahl)

• The use of copper and vanadium mineral ores in catalysed mechanochemical carbon–carbon bond formations. ACS Sustainable Chem. Eng. 2020, 8, 7262–7266
  Puccetti, Francesco; Schumacher, Christian; Wotruba, Hermann; Hernández, José G. & Bolm, Carsten
  
• Mechanistic Insights on the Mechanosynthesis of Phenytoin, a WHO Essential Medicine. Chem. Eur. J. 2022, 28, e202104409
  Puccetti, Francesco; Lukin, Stipe; Užarević, Krunoslav; Colacino, Evelina; Halasz, Ivan; Bolm, Carsten & Hernández, José G.